午夜探花

狈贵-魏叠 is a critical mediator of post-mitotic senescence in oligodendrocytes and subsequent white matter loss
Schlett JS, Mettang M, Skaf A, Schweizer P, Errerd A, Mulugeta EA, Hein TM, Tsesmelis K, Tsesmelis M, B眉ttner UFG, Wendt H, Abaei A, Rasche V, Prex V, Nespoli E, Alami NO, Tews D, Walther P, Yilmazer-Hanke D, Oswald F, Dimou L, Wirth T, Baumann B.

The PMN-MDSC - A key player in glucocorticoid resistance following combined physical and psychosocial trauma
Kempter E, Amoroso M, Kupfer S, Lupu L, Kustermann M, Scheurer J, Baumann B, Wirth T, G眉ndel H, Straub RH, Strau脽 G, Huber-Lang M, Langgartner D, Reber SO.

A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency
IRF4 International Consortium; Fornes O, Jia A, Kuehn HS, Min Q, Pannicke U, Schleussner N, Thouenon R, Yu Z, de Los Angeles Astbury M, Biggs CM, Galicchio M, Garcia-Campos JA, Gismondi S, Gonzalez Villarreal G, Hildebrand KJ, H枚nig M, Hou J, Moshous D, Pittaluga S, Qian X, Rozmus J, Schulz AS, Staines-Boone AT, Sun B, Sun J, Uwe S, Venegas-Montoya E, Wang W, Wang X, Ying W, Zhai X, Zhou Q, Akalin A, Andr茅 I, Barth TFE, Baumann B, Br眉stle A, Burgio G, Bustamante JC, Casanova JL, Casarotto MG, Cavazzana M, Chentout L, Cockburn IA, Costanza M, Cui C, Daumke O, Del Bel KL, Eibel H, Feng X, Franke V, Gebhardt JCM, G枚tz A, Grunwald S, Hoareau B, Hughes TR, Jacobsen EM, Janz M, Jolma A, Lagresle-Peyrou C, Lai N, Li Y, Lin S, Lu HY, Lugo-Reyes SO, Meng X, M枚ller P, Moreno-Corona N, Niemela JE, Novakovsky G, Perez-Caraballo JJ, Picard C, Poggi L, Puig-Lombardi ME, Randall KL, Reisser A, Schmitt Y, Seneviratne S, Sharma M, Stoddard J, Sundararaj S, Sutton H, Tran LQ, Wang Y, Wasserman WW, Wen Z, Winkler W, Xiong E, Yang AWH, Yu M, Zhang L, Zhang H, Zhao Q, Zhen X, Enders A, Kracker S, Martinez-Barricarte R, Mathas S, Rosenzweig SD, Schwarz K, Turvey SE, Wang JY. A

Functional IKK/狈贵-魏叠 signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis
Chan LK, Tsesmelis M, Gerstenlauer M, Leith盲user F, Kleger A, Frick LD, Maier HJ, Wirth T. Functional IKK/狈贵-魏叠 signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis.

T Cell Specific BOB.1/OBF.1 Expression Promotes Germinal Center Response and T Helper Cell Differentiation
Betzler AC, Ezi膰 J, Abou Kors T, Hoffmann TK, Wirth T, Brunner C.

BOB.1/OBF.1 is required during B-cell ontogeny for B-cell differentiation and germinal center function
Betzler AC, Fiedler K, Hoffmann TK, Fehling HJ, Wirth T, Brunner C.

Differential Requirement of Vav Proteins for Btk-dependent and -Independent Signaling During B Cell Development
Betzler AC, Kieser S, Fiedler K, Laban S, Theodoraki MN, Schuler PJ, Wirth T, Tedford K, Fischer KD, Hoffmann TK, Brunner C.

CCND3 is indispensable for the maintenance of B-cell acute lymphoblastic leukemia
Ketzer F, Abdelrasoul H, Vogel M, Marienfeld R, M眉schen M, Jumaa H, Wirth T, Ushmorov A.

 

BOB. 1/OBF. 1 is required during B cell ontogeny for B cell differentiation and germinal center function
Betzler, A. C., Fiedler, K., Hoffmann, T. K., Fehling, H. J., Wirth, T., & Brunner, C.

Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation
Pan L, Hoffmeister P, Turkiewicz A, Huynh NND, Gro脽e-Berkenbusch A, Knippschild U, Gebhardt JCM, Baumann B, Borggrefe T, Oswald F.

IKK2/狈贵-魏叠 Activation in Astrocytes Reduces amyloid 尾 Deposition: A Process Associated with Specific Microglia Polarization
Yang, S., Magnutzki, A., Alami, N. O., Lattke, M., Hein, T. M., Scheller, J. S., Kr枚ger, C., Oswald, F., Yilmazer-Hanke, D., & Wirth, T

Hyperstable SGK1 steps out of AKT鈥檚 shadow
Gehringer, F., & Ushmorov, A.

Deletion of NEMO Inhibits EMT and Reduces Metastasis in KPC Mice
Tsesmelis, M., Tiwary, K., Steiger, K., Sperb, N., Gerstenlauer, M., Manfras, U., Maier, H. J., Hermann, P. C., Chan, L. K., & Wirth, T

Impaired Peyer's patch development in BOB. 1/OBF. 1鈥恉eficient mice
Betzler, A. C., Fiedler, K., Kokai, E., Wirth, T., Hoffmann, T. K., & Brunner, C.

miR-146a regulates insulin sensitivity via NPR3
Roos J, Dahlhaus M, Funcke JB, Kustermann M, Strauss G, Halbgebauer D, Boldrin E, Holzmann K, M枚ller P, Trojanowski BM, Baumann B, Debatin KM, Wabitsch M, Fischer-Posovszky P.

蠅鈥怚midazolyl鈥恆lkyl derivatives as new preclinical drug candidates for treating non鈥恆lcoholic steatohepatitis
Diesinger, T., Lautwein, A., Buko, V., Belonovskaya, E., Lukivskaya, O., Naruta, E., Kirko, S., Andreev, V., Dvorsky, R., & Buckert, D

A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma
Diesinger, T., Lautwein, A., Bergler, S., Buckert, D., Renz, C., Dvorsky, R., Buko, V., Kirko, S., Schneider, E., & Kuchenbauer, F.

 

Multiplexed chemogenetics in astrocytes and motoneurons restore blood-spinal cord barrier in ALS
Ouali Alami N, Tang L, Wiesner D, Commisso B, Bayer D, Weishaupt J, Dupuis L, Wong P, Baumann B, Wirth T, Boeckers TM, Yilmazer-Hanke D, Ludolph Al, Roselli F.

Crosstalk between Tumor and Stromal Cells in Pancreatic Ductal Adenocarcinoma
Sperb N, Tsesmelis M, Wirth T.

Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis
Diesinger T, Buko V, Lautwein A, Dvorsky R, Belonovskaya E, Lukivskaya O, Naruta E, Kirko S, Andreev V, Buckert D, Bergler S, Renz C, Schneider E, Kuchenbauer F, Kumar M, B眉chele B, Simmet T, M眉ller-Ennoch D, Wirt T, Haehner T.

Physiological levels of the PTEN-PI3K-AKT axis activity are required for maintenance of Burkitt lymphoma.
Gehringer F, Weissinger SE, M枚ller P, Wirth T, Ushmorov A.

Elevated 尾-cell stress levels promote severe diabetes development in mice with MODY4.
Trojanowski B, Salem HH, Neubauer H, Simon E, Wagner M, Dorajo R, Boehm BO, Labriola L, Wirth T, Baumann B.

 

STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
Olde Heuvel F, Holl S, Chandrasekar A, Li Z, Wang Y, Rehman R, F枚rstner P, Sinske D, Palmer A, Wiesner D, Ludolph A, Huber-Lang M, Relja B, Wirth T, R枚szer T, Baumann B, Boeckers T, Kn枚ll B, Roselli F.

Oncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis.
Lu M, Hartmann D, Braren R, Gupta A, Wang B, Wang Y, Mogler C, Cheng Z, Wirth T, Friess H, Kleeff J, H眉ser N, Sunami Y.

Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.
O'Connor T, Zhou X, Kosla J, Adili A, Garcia Beccaria M, Kotsiliti E, Pfister D, Johlke AL, Sinha A, Sankowski R, Schick M, Lewis R, Dokalis N, Seubert B, H枚chst B, Inverso D, Heide D, Zhang W, Weihrich P, Manske K, Wohlleber D, Anton M, Hoellein A, Seleznik G, Bremer J, Bleul S, Augustin HG, Scherer F, Koedel U, Weber A, Protzer U, F枚rster R, Wirth T, Aguzzi A, Meissner F, Prinz M, Baumann B, H枚pken UE, Knolle PA, von Baumgarten L, Keller U, Heikenwalder M.

An IKK/NF-kB Activation/p53 Deletion Sequence Drives Liver Carcinogenesis and Tumor Differentiation.
Svinarenko M, Katz SF, Tharehalli U, Mulaw MA, Maier HJ, Sunami Y, Fischer SK, Chen Y, Heurich S, Erkert L, Tannapfel A, Wirth T, Schirmbeck R, Seufferlein T, Lechel A.

FOXO1 Confers Maintenance of the Dark Zone Proliferation and Survival Program and Can Be Pharmacologically Targeted in Burkitt Lymphoma.
Gehringer F, Weissinger SE, Swier LJ, M枚ller P, Wirth T, Ushmorov A.

Block of NF-kB signaling accelerates MYC-driven hepatocellular carcinogenesis and modifies the tumor phenotype towards combined hepatocellular cholangiocarcinoma.
He J, Gerstenlauer M, Chan LK, Leith盲user F, Yeh MM, Wirth T, Maier HJ.

 

FOXO in B-cell lymphopoiesis and B cell neoplasia.
Ushmorov A, Wirth T.

IKK2/NF-kB signaling protects neurons after traumatic brain injury.
Mettang M, Reichel SN, Lattke M, Palmer A, Abaei A, Rasche V, Huber-Lang M, Baumann B, Wirth T.

Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute lymphoblastic leukemia.
Wang F, Demir S, Gehringer F, Osswald CD, Seyfried F, Enzenm眉ller S, Eckhoff SM, Maier T, Holzmann K, Debatin KM, Wirth T, Meyer LH, Ushmorov A.

Fine-tuning of FOXO3A in cHL as a survival mechanism and a hallmark of abortive plasma cell differentiation.
Osswald CD, Xie L, Guan H, Herrmann F, Pick SM, Vogel MJ, Gehringer F, Chan FC, Steidl C, Wirth T, Ushmorov A.

狈贵-魏叠 activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS.
Ouali Alami N, Schurr C, Olde Heuvel F, Tang L, Li Q, Tasdogan A, Kimbara A, Nettekoven M, Ottaviani G, Raposo C, R枚ver S, Rogers-Evans M, Rothenh盲usler B, Ullmer C, Fingerle J, Grether U, Knuesel I, Boeckers TM, Ludolph A, Wirth T, Roselli F, Baumann B.

Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration. 
Lattke M, Reichel SN, Magnutzki A, Abaei A, Rasche V, Walther P, Calado DP, Ferger B, Wirth T, Baumann B.

狈贵-魏叠-mediated astrocyte dysfunction initiates neurodegeneration.
Lattke M, Reichel SN, Baumann B.

Activation of oncogenic pathways in classical Hodgkin lymphoma by decitabine: A rationale for combination with small molecular weight inhibitors.
Swerev TM, Wirth T, Ushmorov A.

FOXO in B-cell lymphopoiesis and B cell neoplasia.
Ushmorov A, Wirth T.
 

A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence.
Meyer P, Maity P, Burkovski A, Schwab J, M眉ssel C, Singh K, Ferreira FF, Krug L, Maier HJ, Wlaschek M, Wirth T, Kestler HA, Scharffetter-Kochanek

Epithelial NEMO/IKK? limits fibrosis and promotes regeneration during pancreatitis.
Chan LK, Gerstenlauer M, Konukiewitz B, Steiger K, Weichert W, Wirth T, Maier HJ

The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6. 
Stauss D, Brunner C, Berberich-Siebelt F, H枚pken UE, Lipp M, M眉ller G;
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Canonical 狈贵-魏叠 signaling in hepatocytes acts as a tumor-suppressor in HBV surface antigen-driven HCC by controlling the UPR. 
Sunami Y, Ringelhan M, Kokai E, Lu M, O'Connor T, Lorentzen A, Weber A, Rodewald AK, M眉llhaupt B, Terracciano L, Gul S, Wissel S, Leith盲user F, Krappmann D, Riedl P, Hartmann D, Schirmbeck R, Strnad P, H眉ser N, Kleeff J, Friess H, Schmid RM, Geisler F, Wirth T, Heikenwalder M;

Activation of oncogenic pathways in classical Hodgkin lymphoma by decitabine: A rationale for combination with small molecular weight inhibitors. 
Swerev TM, Wirth T, Ushmorov A;

Epithelial NEMO/IKK纬 limits fibrosis and promotes regeneration during pancreatitis.
Chan LK, Gerstenlauer M, Konukiewitz B, Steiger K, Weichert W, Wirth T, Maier HJ;

Repression of TCF3/E2A contributes to Hodgkin lymphomagenesis. 
Guan H, Xie L, Wirth T, Ushmorov A;

A paired comparison between glioblastoma "stem cells" and differentiated cells.
Schneider M1, Str枚bele S, Nonnenmacher L, Siegelin MD, Tepper M, Stroh S, Hasslacher S, Enzenm眉ller S, Strauss G, Baumann B, Karpel-Massler G, Westhoff MA, Debatin KM, Halatsch ME.

Cardiac-Specific Activation of IKK2 Leads to Defects in Heart Development and Embryonic Lethality. B盲rbel Kraut, Harald J. Maier, Enik枚 K贸kai, Katja Fiedler, Thomas Boettger, Annett Illing, Sawa Kostin, Paul Walther, Thomas Braun, and Thomas Wirth; PLoS One. 2015 Nov 5;10(11):e0141591. doi: 10.1371; PLoS One. 2015; 

狈贵-魏叠-dependent signals control BOB.1/OBF.1 and Oct2 transcriptional activity in B cells. Kilzheimer M, Quandt J, Langhans J, Weihrich P, Wirth T, Brunner C; Eur J Immunol. 2015 Dec;45(12):3441-53. doi: 10.1002/eji.201545475. Eur J Immunol. 

Neuronal redox imbalance results in altered energy homeostasis and early postnatal lethality. Maity-Kumar G, Thal DR, Baumann B, Scharffetter-Kochanek K, Wirth T; FASEB J. 

The Golgi-Localized 纬-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-尾 Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1). von Einem B, Wahler A, Schips T, Serrano-Pozo A, Proepper C, Boeckers TM, Rueck A, Wirth T, Hyman BT, Danzer KM, Thal DR, von Arnim CA; PLoS One 

Differential regulation of 狈贵-魏叠-mediated proviral and antiviral host gene expression by primate lentiviral Nef and Vpu proteins. Sauter D, Hotter D, Van Driessche B, St眉rzel CM, Kluge SF, Wildum S, Yu H, Baumann B, Wirth T, Plantier JC, Leoz M, Hahn BH, Van Lint C, Kirchhoff F; Cell Rep. 

Tumor necrosis factor-alpha confers cardioprotection through ectopic expression of keratins K8 and K18. Papathanasiou S, Rickelt S, Soriano ME, Schips TG, Maier HJ, Davos CH, Varela A, Kaklamanis L, Mann DL, Capetanaki Y; Nature Medicine 2015

HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization. Azoitei N, Diepold K, Brunner C, Rouhi A, Genze F, Becher A, Kestler H, van Lint J, Chiosis G, Koren J 3rd, Froehling S, Scholl C, Seufferlein T.; Cancer Res. 2014 Oct 8. pii: canres.1017.2014.

FOXO1 repression contributes to block of plasma cell differentiation in classical Hodgkin Lymphoma. Vogel MJ, Xie L, Guan H, Tooze RM, Maier T, Kostezka U, Maier HJ, Holzmann K, Chun Chan F, Steidl C, Reichel JB, Weitzer CD, Gehringer F, Kick AB, Cesarman E, Roshal M, Gascoyne RD, M枚ller P, Wirth T, Ushmorov A.; Blood. 2014 Sep 17. pii: blood-2014-07-590570.

FOXO1 downregulation contributes to the oncogenic program of primary mediastinal B-cell lymphoma. Xie L, Ritz O, Leith盲user F, Guan H, F盲rbinger J, Weitzer CD, Gehringer F, Bruederlein S, Holzmann K, Vogel MJ, M枚ller P, Wirth T, Ushmorov A.; Oncotarget. 2014 Jul 30;5(14):5392-402.

Targeting the intratumor heterogeneity in PMBL. Ritz O, M枚ller P, Ushmorov A.; Cell Cycle. 2014 Jul 15;13(15).

Long-term IKK2/狈贵-魏叠 signaling in pancreatic 尾-cells induces immune-mediated diabetes. Salem HH, Trojanowski B, Fiedler K, Maier HJ, Schirmbeck R, Wagner M, Boehm BO, Wirth T, Baumann B.; Diabetes. 2014 Mar;63(3):960-75. doi: 10.2337/db13-1037.

MYCN and survivin cooperatively contribute to malignant transformation of fibroblasts. Hipp NI, Christner L, Wirth T, Mueller-Klieser W, Walenta S, Schr枚ck E, Debatin KM, Beltinger C.; Carcinogenesis. 2014 Feb;35(2):479-88. doi: 10.1093/carcin/bgt341.

Deficiency of innate and acquired immunity caused by an IKBKB mutation. Pannicke U, Baumann B, Fuchs S, Henneke P, Rensing-Ehl A, Rizzi M, Janda A, Hese K, Schlesier M, Holzmann K, Borte S, Laux C, Rump EM, Rosenberg A, Zelinski T, Schrezenmeier H, Wirth T, Ehl S, Schroeder ML, Schwarz K.; N Engl J Med. 2013 Dec 26;369(26):2504-14. doi: 10.1056/NEJMoa1309199.

The dynactin p150 subunit: cell biology studies of sequence changes found in ALS/MND and Parkinsonian syndromes. Stockmann M, Meyer-Ohlendorf M, Achberger K, Putz S, Demestre M, Yin H, Hendrich C, Linta L, Heinrich J, Brunner C, Proepper C, Kuh GF, Baumann B, Langer T, Schwalenst枚cker B, Braunstein KE, von Arnim C, Schneuwly S, Meyer T, Wong PC, Boeckers TM, Ludolph AC, Liebau S.; J Neural Transm. 2013 May;120(5):785-98. doi: 10.1007/s00702-012-0910-z. Epub 2012 Nov 11.

MYCN and survivin cooperatively contribute to malignant transformation of fibroblasts. Hipp NI, Christner L, Wirth T, Mueller-Klieser W, Walenta S, Schr枚ck E, Debatin KM, Beltinger C.; Carcinogenesis. 2013 Nov 16. 

Inhibition of 狈贵-魏叠 Signaling Ablates the Invasive Phenotype of Glioblastoma. Westhoff MA, Zhou S, Nonnenmacher L, Karpel-Massler G, Jennewein C, Schneider M, Halatsch ME, Carragher NO, Baumann B, Krause A, Simmet T, Bachem MG, Wirtz CR, Debatin KM.; Mol Cancer Res. 2013 Dec;11(12):1611-23. doi: 10.1158/1541-7786.MCR-13-0435-T. Epub 2013 Oct 21. PMID: 24145173

Sustained, neuron-specific IKK/狈贵-魏叠 activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging. Maqbool A, Lattke M, Wirth T, Baumann B.; Mol Neurodegener. 2013 Oct 12;8:40. doi: 10.1186/1750-1326-8-40. PMID: 24119288  

TBX3 Directs Cell-Fate Decision toward Mesendoderm. Weidgang CE, Russell R, Tata PR, K眉hl SJ, Illing A, M眉ller M, Lin Q, Brunner C, Boeckers TM, Bauer K, Kartikasari AE, Guo Y, Radenz M, Bernemann C, Wei脽 M, Seufferlein T, Zenke M, Iacovino M, Kyba M, Sch枚ler HR, K眉hl M, Liebau S, Kleger A.; Stem Cell Reports. 2013 Aug 29;1(3):248-65. doi: 0.1016/j.stemcr.2013.08.002.

CHOP-mediated hepcidin suppression modulates hepatic iron load. Mueller K, Sunami Y, Stuetzle M, G眉ldiken N, Kucukoglu O, Mueller S, Kulaksiz H, Schwarz P, Strnad P.; J Pathol. 2013 Jun 8. doi: 10.1002/path.4221.

MyD88 is involved in myeloid as well as lymphoid hematopoiesis independent of the presence of a pathogen. Fiedler K, Kokai E, Bresch S, Brunner C.; Am J Blood Res. 2013 May 5;3(2):124-40. Print 2013.

Apoptotic and inflammatory signaling via Fas and tumor necrosis factor receptor I contribute to the development of chest trauma-induced septic acute lung injury. Weckbach S, Hohmann C, Denk S, Kellermann P, Huber-Lang MS, Baumann B, Wirth T, Gebhard F, Bachem M, Perl M.; J Trauma Acute Care Surg. 2013 Mar;74(3):792-800. doi: 10.1097/TA.0b013e31827a3655. PMID: 23425737

Octamer-dependent transcription in T cells is mediated by NFAT and 狈贵-魏叠. Mueller K, Quandt J, Marienfeld RB, Weihrich P, Fiedler K, Claussnitzer M, Laumen H, Vaeth M, Berberich-Siebelt F, Serfling E, Wirth T, Brunner C.; Nucleic Acids Res. 2013 Feb 1;41(4):2138-54.

Decitabine represses translocated MYC oncogene in Burkitt lymphoma. Guan H, Xie L, Klapproth K, Weitzer CD, Wirth T, Ushmorov A.; J Pathol. 2013 Jan 23. doi: 10.1002/path.4164. 

Anti-inflammatory therapy in type 1 diabetes. Baumann B, Salem HH, Boehm BO.; Curr Diab Rep. 2012 Oct;12(5):499-509

The role of transcription factors in the guidance of granulopoiesis. Fiedler K, Brunner C.; Am J Blood Res. 2012;2(1):57-65

Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men. M眉ller M, Stockmann M, Malan D, Wolheim A, Tischendorf M, Linta L, Katz SF, Lin Q, Latz S, Brunner C, Wobus AM, Zenke M, Wartenberg M, Boeckers TM, von Wichert G, Fleischmann BK, Liebau S, Kleger A.; Stem Cell Rev. 2012 Sep;8(3):720-40. doi: 10.1007/s12015-011-9324-9. No abstract available. PMID: 22038332

Expression of constitutively active FoxO3 in murine forebrain leads to a loss of neural progenitors. Schmidt-Strassburger U, Schips TG, Maier HJ, Kloiber K, Mannella F, Braunstein KE, Holzmann K, Ushmorov A, Liebau S, Boeckers TM, Wirth T.; FASEB J. 2012 Aug 30. [Epub ahead of print] PubMed PMID: 22935140.

Nuclear Factor 魏B Activation Impairs Ependymal Ciliogenesis and Links Neuroinflammation to Hydrocephalus Formation.  Lattke M, Magnutzki A, Walther P, Wirth T, Baumann B.; J Neurosci. 2012 Aug 22;32(34):11511-23.

Astrocyte-specific IKK2 activation in mice is sufficient to induce neuroinflammation but does not increase susceptibility to MPTP. Oeckl P, Lattke M, Wirth T, Baumann B, Ferger B.; Neurobiol Dis. 2012 Jun 30;48(3):481-487. [Epub ahead of print] PubMed PMID: 22750522.

Cardiomyocyte-specific I魏B kinase (IKK)/狈贵-魏叠 activation induces reversible inflammatory cardiomyopathy and heart failure. Maier HJ, Schips TG, Wietelmann A, Kr眉ger M, Brunner C, Sauter M, Klingel K, B枚ttger T, Braun T, Wirth T.; Proc Natl Acad Sci U S A.; 2012 Jul 2.

Requirement of NEMO/IKK纬 for effective expansion of KRAS-induced precancerous lesions in the pancreas. Maier HJ, Wagner M, Schips TG, Salem H, Baumann B, Wirth T.; Oncogene, 2012;

I魏B kinase/nuclear factor 魏B-dependent insulin-like growth factor 2 (Igf2) expression regulates synapse formation and spine maturation via Igf2 receptor signaling. Schmeisser MJ, Baumann B, Johannsen S, Vindedal GF, Jensen V, Hvalby 脴C, Sprengel R, Seither J, Maqbool A, Magnutzki A, Lattke M, Oswald F, Boeckers TM, Wirth T.; J Neurosci. 2012 Apr 18;32(16):5688-703.

Hepatic activation of IKK/狈贵-魏叠 signaling induces liver fibrosis via macrophage-mediated chronic inflammation. Sunami Y, Leith盲user F, Gul S, Fiedler K, G眉ldiken N, Espenlaub S, Holzmann KH, Hipp N, Sindrilaru A, Luedde T, Baumann B, Wissel S, Kreppel F, Schneider M, Scharffetter-Kochanek K, Kochanek S, Strnad P, Wirth T.; Hepatology. 2012 Mar 12. doi: 10.1002/hep.25711.  

FOXO1 is a tumor suppressor in classical Hodgkin lymphoma. Xie L, Ushmorov A, Leith盲user F, Guan H, Steidl C, F盲rbinger J, Pelzer C, Vogel MJ, Maier HJ, Gascoyne RD, M枚ller P, Wirth T.; Blood. 2012 Apr 12;119(15):3503-11. Epub 2012 Feb 17.

Mechanisms Controlling Hematopoiesis, Hematology - Science and Practice. Fiedler, K., Brunner, C.; Dr. Charles Lawrie (Ed.), ISBN: 978-953-51-0174-1, InTech,

Intestinal carcinogenesis: IKK can go all the way. Sunami Y, Wirth T.; J Clin Invest. 2011 Jul; 121(7):2551-3.  

FoxO3 induces reversible cardiac atrophy and autophagy in a transgenic mouse model. Schips TG, Wietelmann A, H枚hn K, Schimanski S, Walther P, Braun T, Wirth T, Maier HJ.; Cardiovasc Res. 2011 Sep 1; 91(4):587-97. Epub 2011 May 30.

Inflammation, regeneration, and transformation in the pancreas: results of the Collaborative Research Center 518 (SFB 518) at the University of Ulm. Giehl K, Bachem M, Beil M, B枚hm BO, Ellenrieder V, Fulda S, Gress TM, Holzmann K, Kestler HA, Kornmann M, Menke A, M枚ller P, Oswald F, Schmid RM, Schmidt V, Schirmbeck R, Seufferlein T, von Wichert G, Wagner M, Walther P, Wirth T, Adler G.; Pancreas. 2011 May; 40(4):489-502.

Epithelial-Mesenchymal Transition in Pancreatic Carcinoma. Maier HJ , Wirth T,  Beug H; Cancers, 2010; 2, 2058-2083.

KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classical Hodgkin lymphoma. Guan H, Xie L, Leith盲user F, Flossbach L, M枚ller P, Wirth T, Ushmorov A; Blood, 2010;

Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics. Rausch V, Liu L, Kallifatidis G, Baumann B, Mattern J, Gladkich J, Wirth T, Schemmer P,  B眉chler MW, Z枚ller M, Salnikov AV, Herr I; Cancer Res., 2010;

The zinc-finger protein KCMF1 is overexpressed during pancreatic cancer development and downregulation of KCMF1 inhibits pancreatic cancer development in mice. Beilke S, Oswald F, Genze F, Wirth T, Adler G, Wagner M; Oncogene, 2010 May 17;

狈贵-魏叠 promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells. Maier HJ, Schmidt-Strassburger U, Huber MA, Wiedemann EM, Beug H, Wirth T; Cancer Lett, 2010 Mar 27;

Advances in the understanding of MYC-induced lymphomagenesis.  Klapproth K, Wirth T;  Br J Haematol, Epub 2010 Mar 21;

BI 5700, a selective chemical inhibitor of I魏B Kinase 2, specifically suppresses epithelial-mesenchymal transition and metastasis in mouse models of tumor progression. Huber MA, Maier HJ, Alacaptan M, Wiedemann E, Braunger J, Boehmelt G, Madwed JB, Young ERR, Marshall DR, Pehamberger H, Wirth T, Kraut N, Beug H; Genes & Cancer, 2010; 1:101-114;

Dietary polyphenol quercetin targets pancreatic cancer stem cells. Zhou W, Kallifatidis G, Baumann B, Rausch V, Mattern J, Gladkich J, Giese N, Moldenhauer G, Wirth T, B眉chler MW, Salnikov AV, Herr I.; Int J Oncol. 2010 Sep; 37(3):551-61.

Initiation of Dopaminergic Differentiation of Nurr1(-) Mesencephalic Precursor Cells Depends on Activation of Multiple MAP Kinase Pathways. Sabolek M., Baumann B., Heinrich M., Meyer AK., Herborg A., Liebau S., Maisel M., Hermann A., Ventz K., Schwarz J., Wirth T., Storch A.; Stem Cells. 2009 May 14. [Epub ahead of print]

The IKK2/NF- 魏B-pathway suppresses MYC-induced lymphomagenesis. Klapproth K., Sander S., Marinkovic D., Baumann B., Wirth T.; Blood. 2009 Jul 23. [Epub ahead of print]

Epstein-Barr Virus-Induced Gene-3 is Expressed in Human Atheroma Plaques. Kempe S., Heinz P., Kokai E., Devergne O., Marx N., Wirth T.; Am J Pathol. 2009 175:440-447.

Myc Regulates Embryonic Vascular Permeability and Remodeling. Kokai E, Voss F, Fleischer F, Kempe S, Marinkovic D, Wolburg H, Leith盲user F, Schmidt V, Deutsch U, Wirth T.; Circ Res. 2009 104:1151-1159. Epub 2009 Apr 30.;

TNF伪 promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF- 魏B signaling pathway. Hess K., Ushmorov A., Fiedler J., Brenner RE., Wirth T.;  Bone, 2009 45:367-376. Epub 2009 May 3.;

Repressing the repressor - a new mode of MYC action in lymphomagenesis. Sander, S., Bullinger, L., Wirth, T.; Cell Cyle, 2009; 8:556-559 

Sulforaphane targets pancreatic tumor-initiating cells by 狈贵-魏叠-induced anti-apoptotic signaling. Kallifatidis, G., Rausch, V., Baumann, B., Apel, A., Beckermann, B.M., Groth, A., Mattern, J., Li, Z., Kolb, A., Moldenhauer, G., Altevogt, P., Wirth, T., Werner, J., Schemmer, P., B眉chler, M.W., Salnikov, A.V., Herr, I; Gut, 2009;  

MYC stimulates EZH2 expression by repression of its negative regulator miR-26a. Sander, S., Bullinger, L., Klapproth, K., Fiedler, K., Kestler, H.A., Barth, T.F.E., M枚ller, P., Stilgenbauer, S., Pollack, J.R., Wirth, T; Blood, 2008; 112:4202-4212  medline-abstract

ABF-1 is frequently silenced by promoter methylation in follicular lymphoma, diffuse large B-cell lymphoma and Burkitt's lymphoma. Ushmorov, A., Leith盲user, F., Ritz, O., Barth, T.F., M枚ller, P., Wirth, T; Leukemia, 2008; 22:1942-1944  

Phosphorylation of serine 68 in the I魏 (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-伪-induced 狈贵-魏叠 activity. Palkowitsch L, Leidner J, Ghosh S, Marienfeld RB; J Biol Chem, 2008; 283:76-86  

Identification of lysine residues critical for the transcriptional activity and polyubiquitination of the 狈贵-魏叠 family member RelB. Leidner J, Palkowitsch L, Marienfeld U, Fischer D, Marienfeld R; Biochem J, 2008; 416:117-127  pdf

N-myc augments death and attenuates protective effects of Bcl-2 in trophically stressed neuroblastoma cells. Ushmorov A, Hogarty MD, Liu X, Knauss H, Debatin KM, Beltinger C; Oncogene, 2008; 27: 3424-3434;  

Characterization of sonic hedgehog as a novel 狈贵-魏叠 target gene that promotes 狈贵-魏叠-mediated apoptosis resistance and tumor growth in vivo. Kasperczyk H, Baumann B, Debatin KM, Fulda S; FASEB J, 2008; 23:21-33;  

Genomic aberrations in mantle cell lymphoma detected by interphase fluorescence in situ hybridization. Incidence and clinicopathological correlations. Sander S, Bullinger L, Leupolt E,  Benner A, Kienle D, Katzenberger T, Kalla J, Ott G, M眉ller-Hermelink HK, Barth TF, M枚ller P, Lichter P, D枚hner H, Stilgenbauer S; Haematologica, 2008; 93:641-645  

伪PIX Rho GTPase guanine nucleotide exchange factor regulates lymphocyte functions and antigen receptor signaling. Missy K, Hu B, Schilling K, Harenberg A, Sakk V, Kuchenbecker K, Kutsche K, Fischer KD; Mol Cell Biol, 2008; 28:3776-3789  

BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses. Brunner C, Sindrilaru A, Girkontaite I, Fischer KD, Sunderk枚tter C, Wirth T; EMBO J., 2007; 26:3191-202   

Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo. Baumann B, Wagner M, Aleksic T, von Wichert G, Weber CK, Adler G, Wirth T; J Clin Invest., 2007; 117:1502-13.

c-MYC activation impairs the 狈贵-魏叠 and the interferon response: Implications for the pathogenesis of Burkitt's lymphoma. Schlee M, Holzel M, Bernard S, Mailhammer R, Schuhmacher M, Reschke J, Eick D, Marinkovic D, Wirth T, Rosenwald A, Staudt LM, Eilers M, Baran-Marszak F, Fagard R, Feuillard J, Laux G, Bornkamm GW; Int J Cancer, 2007; 120:1387-95.

Cellular immune reaction in the pancreas is induced by constitutively active I魏B kinase-2. Aleksic T, Baumann B, Wagner M, Adler G, Wirth T, Weber CK; Gut., 2007; 56:227-36.

Enriching suicide gene bearing tumor cells for an increased bystander effect. Unger MM, Wahl J, Ushmorov A, Buechele B, Simmet T, Debatin KM, Beltinger C; Cancer Gene Ther, 2007; 14:30-38. 

Sustained JNK activation in response to tumor necrosis factor is mediated by caspases in a cell type-specific manner. Wicovsky A, Muller N, Daryab N, Marienfeld R, Kneitz C, Kavuri S, Leverkus M, Baumann B, Wajant H; J Biol Chem, 2007; 282:2174-2183.

Strongly reduced alloreactivity and Long-Term Survival Times of Cardiac Allografts in Vav1- and Vav1/Vav2-Knockout Mice. Weckbecker G, Bruns C, Fischer KD, Heusser C, Li J, Metzler B, Morris R, Nuesslein-Hildesheim  B, Raulf F, Wieczorek G, Zenke G; Transplant Int., 2007; 20:353-364.  

The granulocyte receptor carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) directly associates with Vav to promote phagocytosis of human pathogens. Schmitter T, Pils S, Sakk V, Frank R, Fischer KD, Hauck C; Immunol., 2007; 178:3797-3805.  

Mitogenic CD28 Signals Require the Exchange Factor Vav1 to Enhance TCR Signaling at the SLP-76-Vav-Itk Signalosome. Dennehy KM, Elias F, Na SY, Fischer KD, Hunig T, Luhder F;  J Immunol, 2007; 178:1363-1371  

Role of caspases in CD95L- and TRAIL-induced non-apoptotic signaling in pancreatic tumour cells. Siegmund D, Klose S, Zhou D, Baumann B, Roder C, Kalthoff H, Wajant H, Trauzold A; Cell Signal, 2007; 19:1172-1184  

Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, reseistance to therapy, and short survival. Stilgenbauer S, Sander S, Bullinger L, Benner A, Leupolt E, Winkler D, Krober A, Kienle D, Lichter P, Dohner H, Stilgenbauer S; Haematologica, 2007; 92:1242-1245  

Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia. Bullinger L, Rucker FG, Kurz S, Du J, Scholl C, Sander S, Corbacioglu A, Lottaz C, Krauter J, Frohling S, Ganser A, Schlenk RF, Dohner K, Pollak JR, Dohner H; Blood, 2007; 110:1291-1300  

Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice. Leder C, Schwab N, Ip CW, Kroner A, Nave KA, Dornmaier K, Martini R, Wiendl H; Mol Cell Neurosci., 2007; 36:416-424  

Btk expression is controlled by Oct and BOB.1/OBF.1. Brunner C, Wirth T; Nucleic Acids Res. 2006; 34: 1807-15.

BOB.1/OBF.1 - A Critical Regulator of B Cell Function. Brunner C, Wirth T; Current Immunology Reviews, 2006; 2: 3-12.

Epigenic processes play a major role in B-cell-specific gene silencing in classical Hodgkin lymphoma. Ushmorov A, Leith盲user F, Sakk O, Weinh盲usel A, Popov SW, M枚ller P, Wirth T; Blood, 2006; 107: 2493-500.

IKK mediates ischemia-induced neuronal death. Herrmann O, Baumann B, de Lorenzi R, Muhammad S, Zhang W, Kleesiek J, Malfertheiner M, Kohrmann M, Potrovita I, Maegele I, Beyer C, Burke JR, Hasan MT, Bujard H, Wirth T, Pasparakis M, Schwaninger M; NatMed. 2005; 12: 1322-9.

狈贵-魏叠 controls the global pro-inflammatory response in endothelial cells: evidence for the regulation of a pro-atherogenic program. Kempe S, Kestler H, Lasar A, Wirth T; Nucleic Acids Res. 2005; 33: 5308-19.

Bruton's Tyrosine Kinase is involved in innate and adaptive immunity. Brunner C, M眉ller B, Wirth T; Histol Histopathol. 2005; 20: 945-55.

Activation of the I魏B kinase complex is sufficient for neuronal differentiation of PC12 cells. Azoitei N, Baumann B, Wirth T; Neurochem. 2005; 93: 1487-501.

B Cell Hyperresponsiveness and Expansion of Mature Follicular B Cells but not of Marginal Zone B Cells in NFATc2/c3 Double-Deficient Mice Samanata DN, Palmetshofer A, Marinkovic D, Wirth T, Serfling E, Nitschke L; J.Immunol. 2005; 174: 4797-802.

Downregulation of internal enhancer activity contributes to abnormally low immunoglobulin expression in the MedB-1 mediastinal B-cell lymphoma cell line. Ritz O, Leith盲user F, Hasel C, Bruderlein S, Ushmorov A, M枚ller P, Wirth T; J Pathol. 2005; 205: 336-48.

The Role of Bruton's Tyrosine Kinase in innate and adaptive immunity. Brunner C, M眉ller B, Wirth T; Recent Res.Devel. Experimental Med., 2004.  publication

NF-kB: Critical Regulator of Inflammation and the Immune Response. Lasar A, Marienfeld R, Wirth T, Baumann B; Handbook of Experimental Pharmacology Vol. 166/Transcription Factors. eds. S.J. Triezenberg, M. Gossen, J. Kaufmann 2004; pp. 325-76.

Epithelial-mesenchymal transition: 狈贵-魏叠 takes center stage. Huber MA, Beug H, Wirth T; Cell Cycle. 2004; 3: 1477-80.

Identification of novel Myc target genes with a potential role in lymphomagenesis. Marinkovic D, Marinkovic T, Kokai E, Barth T, M枚ller P, Wirth T; Nucleic Acids Res. 2004; 32: 5368-78.

狈贵-魏叠 is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. Huber MA, Azoitei N, Baumann B, Gr眉nert S, Sommer A, Pehamberger H, Kraut N, Beug H, Wirth T; J Clin Invest 2004; 114: 569-81.

Epigenetic silencing of the immunoglobulin heavy chain gene in classical Hodgkin lymphoma-derived cell lines contributes to the loss of immunoglobulin expression. Ushmorov A, Ritz O, Hummel M, Leith盲user F, M枚ller P, Stein H, Wirth T; Blood 2004; 104: 3326-34.

Overexpression of phospholipid-hydroperoxide glutathione peroxidase in human dermal fibroblasts abrogates UVA irradiation-induced expression of interstitial collagenase/matrix metalloproteinase-1 by suppression of phosphatidylcholine hydroperoxide-mediated NF魏B activation and interleukin-6 release. Wenk J, Schuller J, Hinrichs C, Syrovets T, Azoitei N, Podda M, Wlaschek M, Brenneisen P, Schneider LA, Sabiwalsky A, Peters T, Sulyok S, Dissemond J, Schauen M, Krieg T, Wirth T, Simmet T, Scharffetter-Kochanek K; J Biol Chem. 2004; 279: 45634-42.

Reversible lymphomagenesis in conditionally c-MYC expressing mice. Marinkovic D, Marinkovic T, Mahr B, Hess J, Wirth T; Int J Cancer 2004; 110: 336-42.

New roles for Bcl10 in B cell development and LPS response. Fischer KD, Tedford K, Wirth T; Trends in Immunol 2004; 25: 113-6.

Myosin light chain 1 atrial isoform (MLC1A) is expressed in pre-B cells under control of the BOB.1/OBF.1 coactivator. Laumen H, Brunner C, Greiner A, Wirth T; Nucleic Acids Res. 2004; 32: 1577-83.

Differential Emu enhancer activity and expression of BOB.1/OBF.1, Oct 2, PU.1 and immunoglobulin in reactive B-cell populations, B-cell non-Hodgkin lymphomas and Hodgkin lymphomas. Loddenkemper C, Anagnostopoulos I, Hummel M, J枚hrens-Leder K, Foss HD, Jundt F, Wirth T, D枚rken B, Stein H; J Pathol 2004; 202: 60-69.

Expression of the Aldehyde Dehydrogenase 2-like Gene is Controlled by BOB.1/OBF.1 in B Lymphocytes. Brunner C, Laumen H, Kraut N, Wirth T; J Biol Chem 2003; 278: 45231-9.

Critical role of RelB serine 368 for dimerization and p100 stabilisation. Maier HJ, Marienfeld R, Wirth T, Baumann B; J Biol Chem 2003; 278: 39242-50.

Bruton麓s tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in 狈贵-魏叠 activation by Toll-like receptor 4. Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, Walch E, Wirth T, O麓Neill LAJ; J Biol Chem 2003; 278: 26258-64.

Caspase-mediated cleavage converts TRAF1 from a selective modulator of TNF receptor signaling to a general inhibitor of NF- 魏B activation. Henkler F, Baumann B, Fotin-Mleczek M, Weing盲rtner M, Schwenzer R, Peters N, Grane脽 A, Wirth T, Scheurich P, Schmid JA, Wajant H; J Biol Chem 2003; 278: 29216-30.

B-cell-specific transgenic expression of Bc12 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice. Brunner C, Marinkovic D, Klein J, Samardzic T, Mitschke L, Wirth T; J Exp Med 2003; 197: 1205-11.

The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells. Amano H, Amano E, Moll T, Marinkovic D, Ibnou-Zekri N, Martinez-Soria E, Semac I, Wirth T, Nitschke L, Izui S; J Immunol. 2003; 170: 2293-301.

Rocaglamide derivates are potent inhibitors of 狈贵-魏叠 activation in T-cells. Baumann B, Bohnenstengel F, Siegmund D, Wajant H, Weber C, Herr I, Debatin KM, Proksch P, Wirth T; J Biol Chem 2002; 277: 44791-800.

BOB.1/OBF.1 deficiency results in reduction of the marginal zone B cell compartment. Samardzic T, Marinkovic D, Nielsen PJ, Nitschke L, Wirth T; Mol Cell Biol 2002; 22: 8320-31.

Lack of correlation between 狈贵-魏叠 activation and induction of programmed cell death in PC12 pheochromocytoma cells treated with 6-hydroxydopamine or the cannabinoid receptor 1-agonist CP55,940. Erlandsson N, Baumann B, R枚ssler OG, Kaufmann K, Giehl KM, Wirth T, Thiel G; Biochem Pharmacol 2002; 64 487-95.

CD22 regulates early B cell development in BOB.1/OBF.1-deficient mice. Samardzic T, Gerlach J, M眉ller K, Marinkovic D, Hess J, Nitschke L, Wirth T; Eur J Immunol. 2002; 32: 2481-9. 

Neuronal cell death induced by antidepressants: lack of correlation with Egr-1, 狈贵-魏叠 and extracellular signal-regulated protein kinase activation. Bartholom盲 P, Erlandsson N, Kaufmann K, R枚ssler OG, Baumann B, Wirth T, Giehl KM, Thiel G; Biochem Pharmacol. 2002; 63: 1507-1516.

Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease. Jundt F, Kley K, Anagnostopoulos I, Schulze-Probsting K, Greiner A, Mathas S, Scheidereit C, Wirth T, Stein H, Dorken B.; Blood. 2002; 99: 3060-2.

Reduction of marginal zone B cells in CD22-deficient mice. Samardzic T, Marinkovic D, Danzer CP, Gerlach J, Nitschke L, Wirth T; Eur J Immunol. 2002; 32: 561-7.

The IKK-2/I 魏B伪 /狈贵-魏叠 pathway plays a key role in the regulation of CCR3 and eotaxin-1 in fibroblasts. A critical link to dermatitis in I魏B伪-deficient mice. Huber MA, Denk A, Peter RU, Weber L, Kraut N, Wirth T; J Biol Chem. 2002; 277: 1268-75.

Regulation of BOB.1/OBF.1 stability by SIAH. Boehm J, He Y, Greiner A, Staudt L, Wirth T; EMBO J. 2001; 20: 4153-62.

Activation of NF-魏 B via the I 魏 B kinase complex is both essential and sufficient for proinflammatory gene expression in primary endothelial cells. Denk A, Goebeler M, Schmid S, Berberich I, Ritz O, Lindemann D, Ludwig S, Wirth T; J Biol Chem. 2001; 276: 28451-8.

Induction of pre-B cell proliferation after de novo synthesis of the pre-B cell receptor. Hess J, Werner A, Wirth T, Melchers F, Jack HM, Winkler TH; Proc Natl Acad Sci U S A. 2001; 98:1745-50.

Defective octamer-dependent transcription is responsible for silenced immunoglobulin transcription in Reed-Sternberg cells. Theil J, Laumen H, Marafioti T, Hummel M, Lenz G, Wirth T, Stein H.; Blood. 2001; 97: 3191-6.

The B lymphocyte-specific coactivator BOB.1/OBF.1 is required at multiple stages of B-cell development. Hess J, Nielsen PJ, Fischer KD, Bujard H, Wirth T; Mol Cell Biol. 2001; 21: 1531-9.

Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription. Weber CK, Liptay S, Wirth T, Adler G, Schmid RM; Blood. 2001; 97: 496-501.

Suppression of NF- 魏B activity by sulfasalazine is mediated by direct inhibition of I魏B kinases 伪 and 尾. Weber CK, Liptay S, Wirth T, Adler G, Schmid RM; Gastroenterology. 2000; 119: 1209-18.

Up-regulation of BOB.1/OBF.1 expression in normal germinal center B cells and germinal center-derived lymphomas. Greiner A, Muller KB, Hess J, Pfeffer K, Muller-Hermelink HK, Wirth T; Am J Pathol 2000; 156: 501-7.

The BOB.1 / OBF.1 co-activator is essential for octamer-dependent transcription in B cells. Laumen H, Nielsen PJ, Wirth T; Eur J Immunol 2000; 30: 458-69.

Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription. Marafioti T, Hummel M, Foss HD, Laumen H, Korbjuhn P, Anagnostopoulos I, Lammert H, Demel G, Theil J, Wirth T, Stein H; Blood 2000; 95: 1443-50.

Raf induces NF- 魏B by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation. Baumann B, Weber CK, Troppmair J, Whiteside S, Israel A, Rapp UR, Wirth T; Proc Natl Acad Sci U S A 2000; 97: 4615-20.

狈贵-魏叠 transcription factors: critical regulators of hematopoiesis and neuronal survival. Denk A, Wirth T, Baumann B; Cytokine and Growth Fact Rev 2000: 303-320.

狈贵-魏叠 is activated and promotes cell death in focal cerebral ischemia. Schneider A, Martin-Villalba A, Weih F, Vogel J, Wirth T, Schwaninger M; Nat Med 1999; 5: 554-9.

In vivo manipulation of interleukin-2 expression by a retroviral tetracycline (tet)-regulated system. Pitzer C, Schindowski K, Pomer S, Wirth T, Zoller M; Cancer Gene Ther 1999; 6: 139-46.

Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-I Tax1. Blumenthal SG, Aichele G, Wirth T, Czernilofsky AP, Nordheim A, Dittmer J; J Biol Chem 1999; 274: 12910-6.

 

Inhibition of nuclear factor 魏B activation attenuates apoptosis resistance in lymphoid cells. Jeremias I, Kupatt C, Baumann B, Herr I, Wirth T, Debatin KM; Blood 1998; 91: 4624-31.

The mutant plasmacytoma cell line S107 allows the identification of distinct pathways leading to 狈贵-魏叠 activation. Baumann B, Kistler B, Kirillov A, Bergman Y, Wirth T; J Biol Chem 1998; 273: 11448-55.

Induction of nuclear factor-魏B during primary B cell differentiation. Kistler B, Rolink A, Marienfeld R, Neumann M, Wirth T; J Immunol 1998; 160: 2308-17.

 

Molecular genetics of the germinal center reaction. Hess J, Laumen H, M眉ller K, Wirth T; J Cell Physiol 1998: 525-34.

Application of differential cDNA-screening techniques to the identifying of unique gene expression in tumours and lymphocytes. Hess J, Laumen H, Wirth T; Curr Opi Immunol 1998: 125-30.

RelB is a key player for both 魏 B-dependent transcription and demethylation in B cells. Kistler B, Baumann B, Bergman Y, Wirth T; Immunobiology 1997; 198: 24-34.

Identification of target genes of the lymphoid-specific transcription factor Oct2. Pfisterer P, Hess J, Wirth T; Immunobiology 1997; 198: 217-26.

Glutamate-dependent activation of NF- 魏B during mouse cerebellum development. Guerrini L, Molteni A, Wirth T, Kistler B, Blasi F; J Neurosci 1997; 17: 6057-63.

Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells. Zwilling S, Dieckmann A, Pfisterer P, Angel P, Wirth T; Science 1997; 277: 221-5.

 

CRISP-3, a protein with homology to plant defense proteins, is expressed in mouse B cells under the control of Oct2. Pfisterer P, Konig H, Hess J, Lipowsky G, Haendler B, Schleuning WD, Wirth T; Mol Cell Biol 1996; 16: 6160-8.

CD40, but not lipopolysaccharide and anti-IgM stimulation of primary B lymphocytes, leads to a persistent nuclear accumulation of RelB. Neumann M, Wohlleben G, Chuvpilo S, Kistler B, Wirth T, Serfling E, Schimpl A; J Immunol 1996; 157: 4862-9.

A role for nuclear 狈贵-魏叠 in B-cell-specific demethylation of the Ig魏 locus. Kirillov A, Kistler B, Mostoslavsky R, Cedar H, Wirth T, Bergman Y; Nat Genet 1996; 13: 435-41.

Coordinate suppression of myeloma-specific genes and expression of fibroblast-specific genes in myeloma X fibroblast somatic cell hybrids. Reich L, Sharir H, Ber R, Wirth T, Bergman Y, Laskov R; Somat Cell Mol Genet 1996; 22: 1-20.

 

High mobility group protein 2 functionally interacts with the domains of octamer transcription factors. Zwilling S, Konig H, Wirth T; EMBO J 1995; 14:1198-208.

Identification of CD36 as the first gene dependent on the B-cell differentiation factor Oct-2. Konig H, Pfisterer P, Corcoran LM, Wirth T; Genes Dev 1995; 9:1598-607.

Functional characterization of the murine homolog of the B cell-specific coactivator BOB.1/OBF.1. Pfisterer P, Zwilling S, Hess J, Wirth T; J Biol Chem 1995; 270: 29870-80.

Lymphoid- and myeloid-specific activity of the PU.1 promoter is determined by the combinatorial action of octamer and ets transcription factors. Kistler B, Pfisterer P, Wirth T; Oncogene 1995; 11: 1095-106.

 

HMG2 functionally interacts with the POU-domain of octamer transcription factors. Zwilling S, K枚nig H, Wirth T; Embo J 1995: 1198-1208.

Molecular principles of Oct2-mediated gene activationin B cells. Wirth T, Pfisterer P, Annweiler A, Zwilling S, K枚nig H; Immunobiology 1995. 161-170.

Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells. Lernbecher T, Kistler B, Wirth T; Embo J 1994: 4060-4069.

Functional differences between the Oct2 transactivation domains determine the transactivation potential of individual Oct2 isoforms. Annweiler A, Zwilling S, Wirth T; Nucl Acids Res 1994: 4250-8.

The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP. Zwillling S, Annweiler A, Wirth T; Nucl Acids Res 1994: 1655-62.

Differential transactivation potential of Oct1 and Oct2 is determined by additional B-cell-specific activities. Pfisterer P, Annweiler A, Ullmer C, Corcoran LM, Wirth T; Embo J 1994: 1654-63.

Distinct members of the 狈贵-魏叠/Rel transcription factor family are responsible for tissue-specific and inducible gene activation. Lernbecher T, M眉ller U, Wirth T; Nature 1993: 767-770.

TGF-尾 and cyclosporin A inhibit the inducible activity of the IL-2 gene in T-cells through a non-canonical octamer binding site. Lernbecher T, M眉ller U, Wirth T; Mol Cell Biol 1993: 1155-1162,

Analysis of transcriptional stimulation by recombinant Oct proteins in a cell-free system. Annweiler A, Zwilling S, Hipskind RA, Wirth T; J Biol Chem 1993: 2525-2534,

Functional analysis of defined mutations in the immunglobulin heavy-chain enhancer in transgenic mice. Annweiler A, M眉ller U, Wirth T; Nucl Acids Res 1992: 1503-1509,

Oct2 transactivation from a remote enhancer position requires a B-cell-restricted activity. Annweiler A, M眉ller-Immergl眉ck M, Wirth T; Mol Cell Biol 1992: 3107-3116,

Anti-IgM antibodies down modulate mu-enhancer activity and OTF2 levels in LPS-stimulated mouse splenic B-cells. Chen U, Scheuermann R, Wirth T, Gerster T, Roeder RG, Harshman K, Berger C; Nucl Acids Res 1991: 5981-5989,

A strategy for efficient in vitro translation of cDNAs using the rabbit 尾-globin leader sequence. Annweiler A, Hipskind RA, Wirth T; Nucl Acids Res 1991: 3750,

Multiple Oct2 isoforms are generated by alternative splicing. Wirth T, Priess A, Annweiler A, Zwilling S, Oeler B; Nucl Acids res 1991: 43-51,

1988

Nuclear factor 狈贵-魏叠 can functionally interact with its cognate binding site to provide lymphoid-specific promoter function. Wirth T, Baltimore D; Embo J 1988: 3109-3113,

1987

An octamer oligonucleotide placed upstream of a TATA motif is sufficient for lymphoid-specific promoter activity. Wirth T, Staudt L, Baltimore D; Nature 1987: 174-178,

1986

A lymphoid specific protein binding to the octamer motif of immunoglobulin genes. Staudt LM, Singh H, Sen R, Wirth T, Sharp PA, Baltimore D; Nature 1986: 640-643,

1985

Structure and genomic organization of a new family of murine retrovirus - related DNA sequences (MuRRS). Schmidt M, Wirth T, Kr枚ger B, Horak I; Nucl Acids Res 1985: 3461-3470,

1984

Evidence that a major class of mouse endogenous long terminal repeats (LTRs) resulted from recombination between exogenous retroviral LTRs and similar LTR-like elements (LTR-IS). Schmidt M, Gl枚ggler K, Wirth T, Horak I; Proc. Natl. Acad. Sci USA 1984: 6696-6730,

Evidence for mobility of a new family of mouse middle repetitive DNA elements (LTR-IS). Wirth T, Schmidt M, Baumruker T, Horak I; Nucl Acids Res 1984: 3603-3610,

1983

Family of middle repetitive DNA sequences in the mouse genome with structural features of solitary retroviral long terminal repeats. Wirth T, Gl枚ggler K, Baumruker T, Schmidt M, Horak I; Proc. NAtl. Acad Sci USA 1983: 3327-3330,