Completed Theses
Bachelor of Science
2020
- Direct modeling of tumor growth and time to event data**/
- Operating Characteristics of Surrogate Endpoint Methods for Normally Distributed Data**/
- Bayesian Continued Process Verification for Biopharmaceuticals**
- Multiple imputation under not-at-random missingness with application in prediction with qPCR data*
2019
- Qualit盲tsauswertung der Krankenhausversorgung mit Hilfe von Martingal-Methoden f眉r konkurrierende Risiken*
- Circular statistics in a study connecting dentofacial data and wind instrument positioning*
- Modeling of Dose-Exposure Relationships and Model-Based Extrapolation During Early Clinical Development**
2018
- Selection Effects in Bayesian Hierarchical Models**/
- Sample Size Calculation in Time-to Event Trials with Non-Proportional Hazards Using GESTATE**/ Bernd-Streitberg Award
- Stochastische Survivalmethoden in der Versicherungsmathematik
2016
- Sample Size Reassessment in Equivalence Trials with Binary Data**
- A Causal Analysis of Ventilator-Associated Pneumonia in Intensive Care/
2015
- Time-dependent Covariates in the Proportional Subdistribution Hazards Modell
- Zur Varianzsch盲tzung des Mantel-Haenszel-Sch盲tzers des Odds Ratios in stratifizierten Studien
2014
- Incidence rates and competing risks in the history of hospital epidemiology
- Nichtparametrische Sch盲tzung einer 脺bergangswahrscheinlichkeit in einem Nicht-Markov illness-death-Modell mit Hilfe von konkurrierenden Risiken
- Comparison of Different Estimators regarding the Intra-Individual Correlation in Phase I Trials and their Usage for Trial Design**
2013
- The predicitive distribution of the residual variability in the linear model for clinical cross-over rials**/
- Interaktion von Membranpermeabilit盲t und zugrunde liegendem Mortalit盲tsrisiko bei inzidenten Dialyse Patienten der MPO Studie*
Cooperations with
Academic Partners* Industry Partners** International Cooperations***
Master of Science
2020
- Zusammenhang von Schmerz und Funktionalit盲t im pr盲- und postoperativen Verlauf bei Patienten mit Osteoarthrose und deren Bedeutung f眉r die Sterblichkeit*
- General Independent Censoring in Event-Driven Trials with Staggered Entry*
- Absolute risk prediction for nested exposure case-control sampling
- Landmarking for left-truncated competing risk data with applications to pregnancy outcome registries*/
2019
- Ein stabilisierter Aalen-Johansen Sch盲tzer bei kleinen intermedi盲ren Risikomengen: Theorie und praktische Beispiele
- Martingale simulation methods for the Fine-Gray model
- Economic sampling designs for rare time-dependent exposures in complex event histories
- Comparison of Time-To-First-Event and Recurrent Event Methods in Multiple Sclerosis Trials**/***
2018
- Evaluating potential post-treatment preditive and prognostic markers with time-to-event data**
- The statistical analysis if the DEcompressive surgery Plus hypoTHermia for Space Occupying Stroke (DEPTH-SOS) trial, with a view towards mortality and safety*
- Joint Models, Landmarking and the Ulm Osteoarthritis Study*
2017
- Multistate Modeling of Clinical Hold in Randomized Clinical Trials**/
- An Application of BLRM with Covariates for Dose Finding**/
- Modeling time-dependent effects for competing risks endpoints in allogeneic stem cell transplantation - a piecewise constant approach*
2016
- Nested Case-Control Designs and Exposure Density Sampling
- Joint Modelling of Overall Survival and Progression-free Survival**/*** .
- Joint modelling of left-truncated observational studies: unmeasured
baseline covariates as a consequence of delayed study entry/ - Pseudo-Value Regression for the Excess Length-of-Stay and subsequent Quality-of-Life associated with hospital-acquired Infections
2015
- Bayesian decision criteria in clinical development**
- Estimation of pregnancy outcome probabilities in the presence of heavy left-truncation/
- Nelson-Aalen and Aalen-Johansen estimators for randomly left-truncated and right-censored non-Markov multistate models with application to hospital epidemiology/
- Analysis of time-dynamic oncological data - in the presence of a non-occurring event of interest*/***
- Sch盲tzung altersbedingter Herzkreislaufrisiken basierend auf Routinedaten*
- Evaluation of the impact of a clinical hold in survival studies under different assumptions regarding the true effect**
- Handling missing data using longitudinal or time-to-event techniques - Simulation studies and practical implementation in the Ulm Birth Cohort Study (UBCS)*
- Bayesian Phase II Optimization for Time-To-Event Data Based on Historical Information**
- Nonparametric estimation of cumulative incidence functions in the presence of dependent left-truncation with application to pregnancy outcome data
2014
- Planning of clinical survival studies in the presence of competing risks
- Wild bootstrapping Nelson-Aalen estimates with application in health services research*/
- Sample size calculations for overall survival in oncology trials incorporating a biomarker using multistate models**
- Investigating the performance of EWOC designs compared to 3+3 in early oncology trials based on historical data**
- Confidence intervals for the difference of proportions adjusted for covariates**
- Robustification of state space models*/***
Cooperations with
Academic Partners* Industry Partners** International Cooperations***
PhD
2018
- Statistical Evaluation of Non-Standard Time-to-Event Outcomes in Biomedical Research: cumulative PhD where one paper has received the