午夜探花

SFB 1074 Publications

3rd Funding Period (07.2020 - 06.2024)

2024

• Weichenhan D, Riedel A, Sollier E, Toprak UH, Hey J, Breuer K, Wierzbinska JA, Touzart A, Lutsik P, B盲hr M, 脰stlund A, Nilsson T, Jacobsson S, Edler M, Waraky A, Behrens YL, G枚hring G, Schlegelberger B, Steinek C, Harz H, Leonhardt H, Dolnik A, Reinhard D, Bullinger L, Palmqvist L, Lipka DB, Plass C.  Al-tered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13).
• Enzenm眉ller E, Niedermayer A, Seyfried F, M眉nch V, Tews D, Rupp U, Tausch E, Gro脽 A, Fischer-Posovszky P, Walther P, Stilgenbauer S, Kestler HA, Debatin KM, Meyer LH. Venetoclax resistance in acute lymphoblastic leukemia is characterized by increased mitochondrial activity and can be overcome by co-targeting cxidative phosphorylation. .
• Eken JA, Koning MT, Kupcova K, Sep煤lveda Y谩帽ez JH, de Groen RAL, Quinten E, Janssen J, van Bergen CAM, Vermaat JSP, Cleven A, Navarrete MA, Ylstra B, de Jong D, Havranek O, Jumaa H, Veelken H. An-tigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL.
• Schmid VK, Hobeika E. B cell receptor signaling and associated pathways in the pathogenesis of chronic lymphocytic leukemia. .
• Weidner FM, Ikonomi N, Werle SD, Schwab JD, Kestler HA. Gatekeep R: an R Shiny application for the identification of nodes with high dynamic impact in Boolean networks.

2023

• Bamezai S, Pulikkottil AJ, Yadav T, Naidu VM, Mueller J, Mark J, Mandal T, Feder KA, Lehle S, Song C, Rosler R, Wiese S, Hoell JI, Kloetgen A, Karsan A, Kumari A, Wojenski L, Sinha AU, Gonzalez-Menendez I, Quintanilla-Martinez L, Donato E, Trumpp A, Kruse E, Hamperl S, Zou L, Rawat VPS, Buske C. A non-canonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML. .
• Kumar S, Vassallo JD, Nattamai KJ, Hassan A, Karns R, Vollmer A, Soller K, Sakk V, Sacma M, Nemkov T, D'Alessandro A, Geiger H. pH regulates hematopoietic stem cell potential via polyamines.
• Bros茅us J, Hergalant S, Vogt J, Tausch E, Kreuz M, Mottok A, Schneider C, Dartigeas C, Roos-Weil D, Quinquenel A, Moulin C, Ott G, Blanchet O, Tomowiak C, Lazarian G, Rouyer P, Chteinberg E, Bernhart SH, Tournilhac O, Gauchotte G, Lomazzi S, Chapiro E, Nguyen-Khac F, Chery C, Davi F, Hunault M, Houlgatte R, Rosenwald A, Delmer A, Meyre D, B茅n茅 MC, Thieblemont C, Lichter P, Ammerpohl O, Gu茅ant JL; ICGC MMML-Seq Consortium; Gui猫ze R, Martin-Subero JI, Cymbalista F, Feugier P, Siebert R, Stilgenbauer S. Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis.
• Parry EM, Leshchiner I, Gui猫ze R, Johnson C, Tausch E, Parikh SA, Lemvigh C, Bros茅us J, Hergalant S, Messer C, Utro F, Levovitz C, Rhrissorrakrai K, Li L, Rosebrock D, Yin S, Deng S, Slowik K, Jacobs R, Huang T, Li S, Fell G, Redd R, Lin Z, Knisbacher BA, Livitz D, Schneider C, Ruthen N, Elagina L, Taylor-Weiner A, Persaud B, Martinez A, Fernandes SM, Purroy N, Anandappa AJ, Ma J, Hess J, Rassenti LZ, Kipps TJ, Jain N, Wierda W, Cymbalista F, Feugier P, Kay NE, Livak KJ, Danysh BP, Stewart C, Neuberg D, Davids MS, Brown JR, Parida L, Stilgenbauer S, Getz G, Wu CJ. Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome.
• Qi J, Endres S, Yosifov DY, Tausch E, Dheenadayalan RP, Gao X, M眉ller A, Schneider C, Mertens D, Gierschik P, Wist M, Jebaraj BMC, Stilgenbauer S. Acquired BTK mutations associated with resistance to non-covalent BTK inhibitors.

2022

• Urbanek KD, Stilgenbauer S, Mertens D. To 尾 or Not to 尾: How Important Is 尾-Catenin Dependent and Independent WNT Signaling in CLL?
• Sa莽ma M, Matteini F, Mulaw MA, Hageb A, Bogeska R, Sakk V, Vollmer A, MarkaG, Soller K, Milsom MD, Florian MC, Geiger H. Fast and high-fidelity insitu 3D imaging protocol for stem cells and niche components for mouse organs and tissues. STAR Protoc. 2022;3(3):101483. doi:10.1016/j.xpro.2022.101483.
• Donato E, Correia NC, Andresen C, Karpova D, W眉rth R, Klein C, Sohn M, Przybylla A, Zeisberger P, Rothfelder K, Salih HR, Bonig H, Stasik S, R枚llig C, Dolnik A, Bullinger L, Buchholz F, Thiede C, H眉bschmann D, Trumpp A. Retained functional normal and preleukemic HSCs at diagnosis are associated to good prognosis in DNMT3Amut NPM1mut AMLs.
• Ten Hacken E, Sewastianik T, Yin S, Brunsting Hoffmann G, Gruber M, Clement K, Penter L, Redd RA, Ruthen N, Hergalant S, Sholokhova A, Fell G, Parry EM, Broseus J, Guieze R, Lucas F, Hernandez-Sanchez M, Baranowski K, Southard J, Joyal H, Billington L, Regis FFD, Witten E, Uduman M, Knisbacher BA, Li S, Lyu H, Vaisitti T, Deaglio S, Inghirami G, Feugier P, Stilgenbauer S, Tausch E, Davids MS, Getz G, Livak KJ, Bozic I, Neuberg DS, Carrasco RD, Wu CJ. In vivo modeling of CLL transformation to Richter's syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities.
• Knisbacher BA, Lin Z, Hahn CK, Nadeu F, Duran-Ferrer M, Stevenson KE, Tausch E, Delgado J, Barbera-Mourelle A, Taylor-Weiner A, Bousquets-Mu帽oz P, Diaz-Navarro A, Dunford A, Anand S, Kretzmer H, Gutierrez-Abril J, L贸pez-Tamargo S, Fernandes SM, Sun C, Sivina M, Rassenti LZ, Schneider C, Li S, Parida L, Meissner A, Aguet F, Burger JA, Wiestner A, Kipps TJ, Brown JR, Hallek M, Stewart C, Neuberg DS, Mart铆n-Subero JI, Puente XS, Stilgenbauer S, Wu CJ, Campo E, Getz G. Molecular map of chronic lymphocytic leukemia and its impact on outcome.

• Mangolini M, Maiques-Diaz A, Charalampopoulou S, Gerhard-Hartmann E, Bloehdorn J, Moore A, Giachetti G, Lu J, Roamio Franklin VN, Chilamakuri CSR, Moutsopoulos I, Rosenwald A, Stilgenbauer S, Zenz T, Mohorianu I, D'Santos C, Deaglio S, Hodson DJ, Martin-Subero JI, Ringshausen I. Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape.

• Herbst SA, Vesterlund M, Helmboldt AJ, Jafari R, Siavelis I, Stahl M, Schitter EC, Liebers N, Brinkmann BJ, Czernilofsky F, Roider T, Bruch PM, Iskar M, Kittai A, Huang Y, Lu J, Richter S, Mermelekas G, Umer HM, Knoll M, Kolb C, Lenze A, Cao X, 脰sterholm C, Wahnschaffe L, Herling C, Scheinost S, Ganzinger M, Mansouri L, Kriegsmann K, Kriegsmann M, Anders S, Zapatka M, Del Poeta G, Zucchetto A, Bomben R, Gattei V, Dreger P, Woyach J, Herling M, M眉ller-Tidow C, Rosenquist R, Stilgenbauer S, Zenz T, Huber W, Tausch E, Lehti枚 J, Dietrich S. Proteogenomics refines the molecular classification of chronic lymphocytic leukemia.

• Nicol貌 A, Amendt T, El Ayoubi O, Young M, Finzel S, Senel M, Voll RE, Jumaa H. Rheumatoid factor IgM autoantibodies control IgG homeostasis. 

• Wolf C, Maus C, Persicke MRO, Filarsky K, Tausch E, Schneider C, D枚hner H, Stilgenbauer S, Lichter P, H枚fer T, Mertens D. Modeling the B-cell receptor signaling on single cell level reveals a stable network circuit topology between nonmalignant B cells and chronic lymphocytic leukemia cells and between untreated cells and cells treated with kinase inhibitors.

• Patil P, Toprak UH, Seufert J, Braun T, Bernhart SH, Wiehle L, M眉ller A, Schlesner M, Herling M, Lichter P, Stilgenbauer S, Siebert R, Zapatka M. Exploration of whole genome and transcriptome sequencing data lacks evidence for oncogenic viral elements to drive the pathogenesis of T-cell prolymphocytic leukemia.

• Jahn N, Jahn E, Saadati M, Bullinger L, Larson RA, Ottone T, Amadori S, Prior TW, Brandwein JM, Appelbaum FR, Medeiros BC, Tallman MS, Ehninger G, Heuser M, Ganser A, Pallaud C, Gathmann I, Krzykalla J, Benner A, Bloomfield CD, Thiede C, Stone RM, D枚hner H, D枚hner K. Genomic landscape of patients with FLT3-mutated acute myeloid leukemia (AML) treated within the CALGB 10603/RATIFY trial.

• Salmeron-Villalobos J, Egan C, Borgmann V, M眉ller I, Gonzalez-Farre B, Ramis-Zaldivar JE, Nann D, Balagu茅 O, L贸pez-Guerra M, Colomer D, Oschlies I, Klapper W, Glaser S, Ko YH, Bonzheim I, Siebert R, Fend F, Pittaluga S, Campo E, Salaverria I, Jaffe ES, Quintanilla-Martinez L. A unifying hypothesis for PNMZL and PTFL: morphological variants with a common molecular profile.

• Gagliani EK, Gutzwiller LM, Kuang Y, Odaka Y, Hoffmeister P, Hauff S, Turkiewicz A, Harding-Theobald E, Dolph PJ, Borggrefe T, Oswald F, Gebelein B, Kovall RA. A Drosophila Su(H) model of Adams-Oliver Syndrome reveals cofactor titration as a mechanism underlying developmental defects. 

• Murgai A, Sosi膷 I, Gobec M, Lemnitzer P, Proj M, Wittenburg S, Voget R, G眉tschow M, Kr枚nke J, Steinebach C. Targeting the deubiquitinase USP7 for degradation with PROTACs.

• Schmid VK, Khadour A, Ahmed N, Brandl C, Nitschke L, Rajewsky K, Jumaa H, Hobeika E. B cell antigen receptor expression and phosphatidylinositol 3-kinase signaling regulate genesis and maintenance of mouse chronic lymphocytic leukemia.

• Grasedieck S, Cabantog A, MacPhee L, Im J, Ruess C, Demir B, Sperb N, R眉cker FG, D枚hner K, Herold T, Pollack JR, Bullinger L, Rouhi A, Kuchenbauer F. The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangements. 

• Patil P, Hillebrecht S, Chteinberg E, L贸pez C, Toprak UH, Seufert J, Bernhart SH, Kretzmer H, Bergmann AK, Bens S, H枚gel J, M眉ller A, Jebaraj BM, Schrader A, Johansson P, Costa D, Schlesner M, D眉rig J, Herling M, Campo E, Stilgenbauer S, Wiehle L, Siebert R. T-cell prolymphocytic leukemia is associated with deregulation of oncogenic microRNAs on transcriptional and epigenetic level.

• Lenk L, Winterberg D, Vogiatzi F, Laqua A, Spory L, Mayar A, Dietterle A, M眉nch G, Vokuhl C, Richter J, Polson AG, Sch眉ler T, Kahlert UD, Peipp M, Valerius T, Schrappe M, Cario G, Jumaa H, Hobeika E, Br眉ggemann M, Alsadeq A, Schewe DM. Preclinical Evidence for the Efficacy of CD79b Immunotherapy in B-cell Precursor Acute Lymphoblastic Leukemia.

• Jackson RA, Smith VM, Jayne S, Drewes C, Bens S, Siebert R, Dyer MJS, Walter HS. Successful Retreatment With Venetoclax in a Patient With Chronic Lymphocytic Leukemia.

• Ferrante F, Giaimo BD, Friedrich T, Sugino T, Mertens D, Kugler S, Gahr BM, Just S, Pan L, Bartkuhn M, Potente M, Oswald F, Borggrefe T. Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics.

• Datta M, Jumaa H. Immunoglobulin Gene Sequence as an Inherited and Acquired Risk Factor for Chronic Lymphocytic Leukemia. 

• 脫nody A, Veres-Sz茅kely A, Pap D, Rokonay R, Szebeni B, Sziksz E, Oswald F, Veres G, Cseh 脕, Szab贸 AJ, Vannay 脕. Interleukin-24 regulates mucosal remodeling in inflammatory bowel diseases.

• Tausch E, Ljungstr枚m V, Agathangelidis A, Zapatka M, Scarf貌 L, Jebaraj BMC, Yosifov DY, M眉ller A, Munugalavadla V, Degenhardt JD, Ghia P, Rosenquist R, Stilgenbauer S. Secondary resistance to idelalisib is characterized by upregulation of IGF1R rather than MAPK/ERK pathway mutations. 4

• Iaccarino I, Mourtada F, Reinke S, Patil P, Doose G, Monaco G, Hoffmann S, Siebert R, Klapper W. LINC00892 Is an lncRNA Induced by T Cell Activation and Expressed by Follicular Lymphoma-Resident T Helper Cells. 

• Kaymak T, Kaya B, Wuggenig P, Nuciforo S, G枚ldi A; Swiss EoE Cohort Study Group (SEECS), Oswald F, Roux J, Noti M, Melhem H, Hruz P, Niess JH. IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis.

• Platzbecker U, Chromik J, Kr枚nke J, Handa H, Strickland S, Miyazaki Y, Wermke M, Sakamoto W, Tachibana Y, Taube T, Germing U. Volasertib as a monotherapy or in combination with azacitidine in patients with myelodysplastic syndrome, chronic myelomonocytic leukemia, or acute myeloid leukemia: summary of three phase I studies.

• Muranyi A, Ammer T, Kechter A, Rawat VPS, Sinha AU, Gonzalez-Menendez I, Quintanilla-Martinez L, Azoitei A, G眉nes C, Mupo A, Vassiliou GS, Bamezai S, Buske C. Npm1 Haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice.

• Seyfried F, Stirnwei脽 FU, Niedermayer A, Enzenm眉ller S, H枚rl RL, M眉nch V, K枚hrer S, Debatin KM, Meyer LH. Synergistic activity of combined inhibition of anti-apoptotic molecules in B-cell precursor ALL.

• Vadakumchery A, Faraidun H, Ayoubi OE, Outaleb I, Schmid V, Abdelrasoul H, Amendt T, Khadour A, Setz C, G枚hring K, Lodd K, Hitzing C, Alkhatib A, Bilal M, Benckendorff J, Al Shugri AK, Brakebusch CH, Engels N, Datta M, Hobeika E, Alsadeq A, Jumaa H. The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B Cells.

• Roth A, Gihring A, Bischof J, Pan L, Oswald F, Knippschild U. CK1 Is a Druggable Regulator of Microtubule Dynamics and Microtubule-Associated Processes. 

• Bloehdorn J, Krzykalla J, Holzmann K, Gerhardinger A, Jebaraj BMC, Bahlo J, Humphrey K, Tausch E, Robrecht S, Mertens D, Schneider C, Fischer K, Hallek M, D枚hner H, Benner A, Stilgenbauer S. Integrative prognostic models predict long-term survival after immunochemotherapy in chronic lymphocytic leukemia patients.

• Jebaraj BMC, M眉ller A, Dheenadayalan RP, Endres S, Roessner PM, Seyfried F, Walliser C, Wist M, Qi J, Tausch E, Mertens D, Fox JA, Debatin KM, Meyer LH, Taverna P, Seiffert M, Gierschik P, Stilgenbauer S. Evaluation of vecabrutinib as a model for noncovalent BTK/ITK inhibition for treatment of chronic lymphocytic leukemia.  

• Kaddu-Mulindwa D, Altmann B, Robrecht S, Ziepert M, Regitz E, Tausch E, Held G, Poeschel V, Lesan V, Bittenbring JT, Thurner L, Pfreundschuh M, Christofyllakis K, Truemper L, Loeffler M, Schmitz N, Hoth M, Hallek M, Fischer K, Stilgenbauer S, Bewarder M, Rixecker TM. KIR2DS1-HLA-C status as a predictive marker for benefit from rituximab: a post-hoc analysis of the RICOVER-60 and CLL8 trials.

• Popovic R, Dunbar F, Lu C, Robinson K, Quarless D, Warder SE, Mukherjee N, Pesko J, Souers AJ, Waring JF, Davids MS, Tausch E, Stilgenbauer S, Ross JA, Leverson JD, Kim SY, Chyla BJ. Identification of recurrent genomic alterations in the apoptotic machinery in chronic lymphocytic leukemia patients treated with venetoclax monotherapy.

• Pulikkottil AJ, Bamezai S, Ammer T, Mohr F, Feder K, Vegi NM, Mandal T, Kohlhofer U, Quintanilla-Martinez L, Sinha A, Buske C, Rawat VPS. TET3 promotes AML growth and epigenetically regulates glucose metabolism and leukemic stem cell associated pathways.

• Estey E, Hasserjian RP, D枚hner H. Distinguishing AML from MDS: a fixed blast percentage may no longer be optimal.

• Mazzarello AN+, Gentner-G枚bel E+, D眉hren-von Minden M, Tarasenko TN, Nicol貌 A, Ferrer G, Vergani S, Liu Y, Bagnara D, Rai KR, Burger JA, McGuire PJ, Maity PC*, Jumaa H*, Chiorazzi N*. B-cell receptor isotypes differentially associate with cell signaling, kinetics, and outcome in chronic lymphocytic leukemia.

• Renna V, Surova E, Khadour A, Datta M, Amendt T, Hobeika E, Jumaa H. Defective Allelic Exclusion by IgD in the Absence of Autoantigen.  

• Ketzer F, Abdelrasoul H, Vogel M, Marienfeld R, M眉schen M, Jumaa H, Wirth T, Ushmorov A. CCND3 is indispensable for the maintenance of B-cell acute lymphoblastic leukemia.

2021

•  L谩zaro-Navarro J, Pimentel-Guti茅rrez HJ, Gauert A, Hagemann AIH, Eisenschmid J, G枚kbuget N, Vick B, Jeremias I, Seyfried F, Meyer LH, Debatin KM, Richer K, Bultman M, Neumann M, H盲nzelmann S, Serve H, Astrahantseff K, Rieger MA, Eckert C, Baldus CD, Bastian L. Inhibiting casein kinase 2 sensitizes acute lymphoblastic leukemia cells to venetoclax via MCL1 degradation.

• Nicol貌 A, Linder AT, Jumaa H, Maity PC. The Determinants of B Cell Receptor Signaling as Prototype Molecular Biomarkers of Leukemia. 

• Boldrin E, Gaffo E, Niedermayer A, Boer JM, Zimmermann M, Weichenhan D, Claus R, M眉nch V, Sun Q, Enzenm眉ller S, Seyfried F, Demir S, Zinngrebe J, Cario G, Schrappe M, Den Boer ML, Plass C, Debatin KM, Te Kronnie G, Bortoluzzi S, Meyer LH. MicroRNA-497/195 is tumor suppressive and cooperates with CDKN2A/B in pediatric acute lymphoblastic leukemia.

• Cramer P, Tausch E, von Tresckow J, Giza A, Robrecht S, Schneider C, F眉rstenau M, Langerbeins P, Al-Sawaf O, Pelzer BW, Fink AM, Fischer K, Wendtner CM, Eichhorst B, Kneba M, Stilgenbauer S, Hallek M. Durable remissions following combined targeted therapy in patients with CLL harboring TP53 deletions and/or mutations.

• B眉hler A, Gahr BM, Park DD, Bertozzi A, Boos A, Dalvoy M, Pott A, Oswald F, Kovall RA, K眉hn B, Weidinger G, Rottbauer W, Just S. Histone deacetylase 1 controls cardiomyocyte proliferation during embryonic heart development and cardiac regeneration in zebrafish.

• Bricelj A, Dora Ng YL, Ferber D, Kuchta R, M眉ller S, Monschke M, Wagner KG, Kr枚nke J, Sosi膷 I, G眉tschow M, Steinebach C. Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands. 

• Pan L, Hoffmeister P, Turkiewicz A, Huynh NND, Gro脽e-Berkenbusch A, Knippschild U, Gebhardt JCM, Baumann B, Borggrefe T, Oswald F. Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation.

• Schwab JD, Ikonomi N, Werle SD, Weidner FM, Geiger H, Kestler HA. Reconstructing Boolean network ensembles from single-cell data for unraveling dynamics in the aging of human hematopoietic stem cells.  

• Bloehdorn J, Braun A, Taylor-Weiner A, Jebaraj BMC, Robrecht S, Krzykalla J, Pan H, Giza A, Akylzhanova G, Holzmann K, Scheffold A, Johnston HE, Yeh RF, Klymenko T, Tausch E, Eichhorst B, Bullinger L, Fischer K, Weisser M, Robak T, Schneider C, Gribben J, Dahal LN, Carter MJ, Elemento O, Landau DA, Neuberg DS, Cragg MS, Benner A, Hallek M, Wu CJ, D枚hner H, Stilgenbauer S, Mertens D. Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia. 

• Manzano-Mu帽oz A, Alcon C, Men茅ndez P, Ram铆rez M, Seyfried F, Debatin KM, Meyer LH, Samitier J, Montero J. MCL-1 Inhibition Overcomes Anti-apoptotic Adaptation to Targeted Therapies in B-Cell Precursor Acute Lymphoblastic Leukemia.  

• Moulin C, Guillemin F, Remen T, Bouclet F, Hergalant S, Quinquenel A, Dartigeas C, Tausch E, Lazarian G, Blanchet O, Lomazzi S, Chapiro E, Schneider C, Nguyen-Khac F, Davi F, Hunault M, Tomowiak C, Roos-Weil D, Siebert R, Thieblemont C, Cymbalista F, Laribi K, B茅n茅 MC, Stilgenbauer S, Gui猫ze R, Feugier P, Bros茅us J. Clinical, biological, and molecular genetic features of Richter syndrome and prognostic significance: A study of the French Innovative Leukemia Organization.

• Sotomska M, Liefke R, Ferrante F, Schwederski H, Oswald F, Borggrefe T. SUMOylated non-canonical polycomb PRC1.6 complex as a prerequisite for recruitment of transcription factor RBPJ.

• H眉bschmann D, Kleinheinz K, Wagener R, Bernhart SH, L贸pez C, Toprak UH, Sungalee S, Ishaque N, Kretzmer H, Kreuz M, Waszak SM, Paramasivam N, Ammerpohl O, Aukema SM, Beekman R, Bergmann AK, Bieg M, Binder H, Borkhardt A, Borst C, Brors B, Bruns P, Carrillo de Santa Pau E, Claviez A, Doose G, Haake A, Karsch D, Haas S, Hansmann ML, Hoell JI, Hovestadt V, Huang B, Hummel M, J盲ger-Schmidt C, Kerssemakers JNA, Korbel JO, Kube D, Lawerenz C, Lenze D, Martens JHA, Ott G, Radlwimmer B, Reisinger E, Richter J, Rico D, Rosenstiel P, Rosenwald A, Schillhabel M, Stilgenbauer S, Stadler PF, Mart铆n-Subero JI, Szczepanowski M, Warsow G, Weniger MA, Zapatka M, Valencia A, Stunnenberg HG, Lichter P, M枚ller P, Loeffler M, Eils R, Klapper W, Hoffmann S, Tr眉mper L; ICGC MMML-Seq consortium; ICGC DE-Mining consortium; BLUEPRINT consortium, K眉ppers R, Schlesner M, Siebert R. Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas.

• Schmalbrock LK, Dolnik A, Cocciardi S, Str盲ng E, Theis F, Jahn N, Panina E, Bl盲tte TJ, Herzig J, Skambraks S, R眉cker FG, Gaidzik VI, Paschka P, Fiedler W, Salih HR, Wulf G, Schroeder T, L眉bbert M, Schlenk RF, Thol F, Heuser M, Larson RA, Ganser A, Stunnenberg HG, Minucci S, Stone RM, Bloomfield CD, D枚hner H, D枚hner K, Bullinger L. Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin.  

• Panagiota V, Meggendorfer M, Kubasch AS, Gabdoulline R, Kr枚nke J, Mies A, Shahswar R, Kandziora C, Klement P, Schiller J, G枚hring G, Haferlach C, Ganster C, Shirneshan K, Gutermuth A, Thiede C, Germing U, Schroeder T, Kobbe G, Klesse S, Koenecke C, Schlegelberger B, Kr枚ger N, Haase D, D枚hner K, Sperr WR, Valent P, Ganser A, Thol F, Haferlach T, Platzbecker U, Heuser M. Impact of PPM1D mutations in patients with myelodysplastic syndrome and deletion of chromosome 5q.

• V枚lkel G, Laban S, F眉rstberger A, K眉hlwein SD, Ikonomi N, Hoffman TK, Brunner C, Neuberg DS, Gaidzik V, D枚hner H, Kraus JM, Kestler HA.  Analysis, identification and visualization of subgroups in genomics.

• Weidner FM, Schwab JD, Werle SD, Ikonomi N, Lausser L, Kestler HA. Capturing dynamic relevance in Boolean networks using graph theoretical measures.

• Frankenreiter L, Gahr BM, Schmid H, Zimmermann M, Deichsel S, Hoffmeister P, Turkiewicz A, Borggrefe T, Oswald F, Nagel AC. Phospho-Site Mutations in Transcription Factor Suppressor of Hairless Impact Notch Signaling Activity During Hematopoiesis in Drosophila.

• Giaimo BD, Robert-Finestra T, Oswald F, Gribnau J, Borggrefe T. Chromatin Regulator SPEN/SHARP in X Inactivation and Disease.

• Lux S, Bl盲tte TJ, Gillissen B, Richter A, Cocciardi S, Skambraks S, Schwarz K, Schrezenmeier H, D枚hner H, D枚hner K, Dolnik A, Bullinger L. Deregulated expression of circular RNAs in acute myeloid leukemia.

• Bamezai S, Demir D, Pulikkottil AJ, Ciccarone F, Fischbein E, Sinha A, Borga C, Te Kronnie G, Meyer LH, Mohr F, G枚tze M, Caiafa P, Debatin KM, D枚hner K, D枚hner H, Gonz谩lez-Men茅ndez I, Quintanilla-Fend L, Herold T, Jeremias I, Feuring-Buske M, Buske C, Rawat VPS. TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition.

• Jebaraj BMC, Stilgenbauer S. Telomere Dysfunction in Chronic Lymphocytic Leukemia.
  

• Kapp-Schwoerer S, Weber D, Corbacioglu A, Gaidzik VI, Paschka P, Kr枚nke J, Theis F, R眉cker FG, Teleanu MV, Panina E, Jahn N, Herzig J, Kubanek L, Schrade A, G枚hring G, Fiedler W, Kindler T, Schroeder T, Mayer KT, L眉bbert M, Wattad M, G枚tze KS, Horst HA, Koller E, Wulf G, Schleicher J, Bentz M, Krauter J, Bullinger L, Krzykalla J, Benner A, Schlenk RF, Thol F, Heuser M, Ganser A, D枚hner H, D枚hner K. Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1-mutated AML: results from the AMLSG 09-09 trial.

• Wirth M, Schick M, Keller U, Kr枚nke J. Ubiquitination and Ubiquitin-Like Modifications in Multiple Myeloma: Biology and Therapy.

• Lausser L*, Sch盲fer LM*, Kestler HA. Ordinal Classifiers Can Fail on Repetitive *equally contributed

• Lausser L, Sch盲fer LM, K眉hlwein SD, Kestler A, Kestler HA. Detecting Ordinal Subcascades.

• Tausch E, Beck P, Schlenk RF, Jebaraj BJ, Dolnik A, Yosifov DY, Hillmen P, Offner F, Janssens A, Babu GK, Grosicki S, Mayer J, Panagiotidis P, McKeown A, Gupta IV, Skorupa A, Pallaud C, Bullinger L, Mertens D, D枚hner H, Stilgenbauer S. Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia: results from the pivotal phase III study COMPLEMENT1.

• M眉ller A*, Lausser L*, Wilhelm A, Ropinski T, Platzer M, Neumann H**, Kestler HA**. A perceptually optimised bivariate visualisation scheme for high-dimensional fold-change data.  *equal contribution **equally contributing senior authors

2nd Funding Period (07.2016 - 06.2020)

2020

• Ikonomi N*, K眉hlwein SD*, Schwab JD*, Kestler HA. Awakening the HSC: Dynamic Modeling of HSC Maintenance Unravels Regulation of the TP53 Pathway and Quiescence.  *equal contribution
• Lausser L*, Szekely R*, Kestler HA. Chained correlations for feature selection.

• Rawat VPS, G枚tze M, Rasalkar A, Vegi NM, Ihme S, Thoene S, Pastore A, Bararia D, D枚hner H, D枚hner K, Feuring-Buske M, Quintanilla-Fend L, Buske C. The microRNA miR-196b acts as a tumor suppressor in Cdx2-driven acute myeloid leukemia.

• Zinngrebe J, Schlichtig F, Kraus JM, Meyer M, Boldrin E, Kestler HA, Meyer LH, Fischer-Posovszky P, Debatin KM. Biomarker profile for prediction of response to SMAC mimetic monotherapy in pediatric precursor B-cell acute lymphoblastic leukemia.

• Schneider E, Pochert N, Ruess C, MacPhee L, Escano L, Miller C, Krowiorz K, Delsing Malmberg E, Heravi-Moussavi A, Lorzadeh A, Ashouri A, Grasedieck S, Sperb N, Kumar Kopparapu P, Iben S, Staffas A, Xiang P, R枚sler R, Kanduri M, Larsson E, Fogelstrand L, D枚hner H, D枚hner K, Wiese S, Hirst M, Keith Humphries R, Palmqvist L, Kuchenbauer F, Rouhi A. MicroRNA-708 is a novel regulator of the Hoxa9 program in myeloid cells.

• Bamezai S, Demir D, Pulikkottil AJ, Ciccarone F, Fischbein E, Sinha A, Borga C, Te Kronnie G, Meyer LH, Mohr F, G枚tze M, Caiafa P, Debatin KM, D枚hner K, D枚hner H, Gonz谩lez-Men茅ndez I, Quintanilla-Fend L, Herold T, Jeremias I, Feuring-Buske M, Buske C, Rawat VPS. TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition.

• Wist M, Meier L, Gutman O, Haas J, Endres S, Zhou Y, R枚sler R, Wiese S, Stilgenbauer S, Hobeika E, Henis YI, Gierschik P, Walliser C. Noncatalytic Bruton's tyrosine kinase activates PLCy₂ variants mediating ibrutinib resistance in human chronic lymphocytic leukemia cells. J

• Pap D, Veres-Sz茅kely A, Szebeni B, Rokonay R, 脫nody A, Lippai R, Tak谩cs IM, Tisl茅r A, Kardos M, Oswald F, Fekete A, Szab贸 AJ, Vannay 脕. Characterization of IL-19, -20, and -24 in acute and chronic kidney diseases reveals a pro-fibrotic role of IL-24.

• Ferrante F, Giaimo BD, Bartkuhn M, Zimmermann T, Close V, Mertens D, Nist A, Stiewe T, Meier-Soelch J, Kracht M, Just S, Kl枚ble P, Oswald F, Borggrefe T. HDAC3 functions as a positive regulator in Notch signal transduction. .

• Patil P, Cieslak A, Bernhart SH, Toprak UH, Wagener R, L贸pez C, Wiehle L, Bens S, Altm眉ller J, Franitza M, Scholz I, Jayne S, Ahearne MJ, Scheffold A, Jebaraj BMC, Schneider C, Costa D, Braun T, Schrader A, Campo E, Dyer MJS, N眉rnberg P, D眉rig J, Johansson P, B枚ttcher S, Schlesner M, Herling M, Stilgenbauer S, Macintyre E, Siebert R. Reconstruction of rearranged T-cell receptor loci by whole genome and transcriptome sequencing gives insights into the initial steps of T-cell prolymphocytic leukemia.

• Scheffold A, Baig AH, Chen Z, von L枚hneysen SE, Becker F, Morita Y, Avila AI, Groth M, Lechel A, Schmid F, Kraus JM, Kestler HA, Stilgenbauer S, Philipp M, Burkhalter MD. Elevated Hedgehog activity contributes to attenuated DNA damage responses in aged hematopoietic cells.

• Altamura S, Vegi NM, Hoppe PS, Schroeder T, Aichler M, Walch A, Okreglicka K, H眉ltner L, Schneider M, Ladinig C, Kuklik-Roos C, Mysliwietz J, Janik D, Neff F, Rathkolb B, Hrab茅 de Angelis M, Buske C, da Silva AR, Muedder K, Conrad M, Ganz T, Kopf M, Muckenthaler MU, Bornkamm GW. Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis.

• Patil P, Cieslak A, Bernhart SH, Toprak UH, Wagener R, L贸pez C, Wiehle L, Bens S, Altm眉ller J, Franitza M, Scholz I, Jayne S, Ahearne MJ, Scheffold A, Jebaraj BMC, Schneider C, Costa D, Braun T, Schrader A, Campo E, Dyer MJS, N眉rnberg P, D眉rig J, Johansson P, B枚ttcher S, Schlesner M, Herling M, Stilgenbauer S, Macintyre E, Siebert R. Reconstruction of rearranged T-cell receptor loci by whole genome and transcriptome sequencing gives insights into the initial steps of T-cell prolymphocytic leukemia.

• Lenk L, Alsadeq A, Schewe DM. Involvement of the central nervous system in acute lymphoblastic leukemia: opinions on molecular mechanisms and clinical implications based on recent data.

• Maity PC, Bilal M, Koning MT, Young M, van Bergen CAM, Renna V, Nicol貌 A, Datta M, Gentner-G枚bel E, Barendse RS, Somers SF, de Groen RAL, Vermaat JSP, Steinbrecher D, Schneider C, Tausch E, Bittolo T, Bomben R, Mazzarello AN, Del Poeta G, Kroes WGM, van Wezel JT, Imkeller K, Busse CE, Degano M, Bakchoul T, Schulz AR, Mei H, Ghia P, Kotta K, Stamatopoulos K, Wardemann H, Zucchetto A, Chiorazzi N, Gattei V, Stilgenbauer S, Veelken H, Jumaa H. IGLV3-21*01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling.

• Schlenk RF, Paschka P, Krzykalla J, Weber D, Kapp-Schwoerer S, Gaidzik VI, Leis C, Fiedler W, Kindler T, Schroeder T, Mayer K, L眉bbert M, Wattad M, G枚tze K, Horst HA, Koller E, Wulf G, Schleicher J, Bentz M, Greil R, Hertenstein B, Krauter J, Martens U, Nachbaur D, Abu Samra M, Girschikofsky M, Basara N, Benner A, Thol F, Heuser M, Ganser A, D枚hner K, D枚hner H. Gemtuzumab Ozogamicin in NPM1-Mutated Acute Myeloid Leukemia: Early Results From the Prospective Randomized AMLSG 09-09 Phase III Study. .

• Lausser L, Szekely R, Klimmek A, Schmid F, Kestler HA. Constraining classifiers in molecular analysis: invariance and robustness.

• Njeru SN, Kraus J, Meena JK, Lechel A, Katz SF, Kumar M, Knippschild U, Azoitei A, Wezel F, Bolenz C, Leith盲user F, Gollowitzer A, Omrani O, Hoischen C, Koeberle A, Kestler HA, G眉nes C, Rudolph KL. Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor.

• Agrawal M, Schwarz P, Giaimo BD, Bedzhov I, Corbacioglu A, Weber D, Gaidzik VI, Jahn N, R眉cker FG, Schroeder T, Kindler T, Wattad M, G枚tze K, L眉bbert M, Salwender H, Ringhoffer M, Lange E, Koller E, Thol F, Heuser M, Ganser A, Bullinger L, Paschka P, D枚hner H, Geiger H, Borggrefe T, D枚hner K, Oswald F. Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML).

• Meyer T, Jahn N, Lindner S, R枚hner L, Dolnik A, Weber D, Scheffold A, K枚pff S, Paschka P, Gaidzik VI, Heckl D, Wiese S, Ebert BL, D枚hner H, Bullinger L, D枚hner K, Kr枚nke J. Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1).

• D枚hner K, Thiede C, Jahn N, Panina E, Gambietz A, Larson RA, Prior TW, Marcucci G, Jones D, Krauter J, Heuser M, Voso MT, Ottone T, Nomdedeu JF, Mandrekar SJ, Klisovic RB, Wei AH, Sierra J, Sanz MA, Brandwein JM, de Witte T, Jansen JH, Niederwieser D, Appelbaum FR, Medeiros BC, Tallman MS, Schlenk RF, Ganser A, Serve H, Ehninger G, Amadori S, Gathmann I, Benner A, Pallaud C, Stone RM, D枚hner H, Bloomfield CD. Impact of NPM1/FLT3-ITD genotypes defined by the 2017 European LeukemiaNet in patients with acute myeloid leukemia.

• Vegi NM, Chakrabortty S, Zegota MM, Kuan SL, Stumper A, Rawat VPS, Sieste S, Buske C, Rau S, Weil T, Feuring-Buske M. Somatostatin receptor mediated targeting of acute myeloid leukemia by photodynamic metal complexes for light induced apoptosis.

• Tausch E, Beck P, Schlenk RF, Jebaraj BJ, Dolnik A, Yosifov DY, Hillmen P, Offner F, Janssens A, Babu KG, Grosicki S, Mayer J, Panagiotidis P, McKeown A, Gupta IV, Skorupa A, Pallaud C, Bullinger L, Mertens D, D枚hner H, Stilgenbauer S. Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia: results from the pivotal phase III study COMPLEMENT1.

• Demir S, Boldrin E, Sun Q, Hampp S, Tausch E, Eckert C, Ebinger M, Handgretinger R, Kronnie GT, Wiesm眉ller L, Stilgenbauer S, Selivanova G, Debatin KM, Meyer LH. Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia.

• Brown A, Schuetz D, Han Y, Daria D, Nattamai KJ, Eiwen K, Sakk V, Pospiech J, Saller T, van Zant G, Wagner W, Geiger H. The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function.

• Uckelmann HJ, Kim SM, Wong EM, Hatton C, Giovinazzo H, Gadrey JY, Krivtsov AV, R眉cker FG, D枚hner K, McGeehan GM, Levine RL, Bullinger L, Vassiliou GS, Armstrong SA. Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia. Science. 2020 Jan 31;367(6477):586-590.

• Yosifov DY, Idler I, Bhattacharya N, Reichenzeller M, Close V, Ezerina D, Scheffold A, Jebaraj BMC, Kugler S, Bloehdorn J, Bahlo J, Robrecht S, Eichhorst B, Fischer K, Weigel A, Busch H, Lichter P, D枚hner H, Dick TP, Stilgenbauer S, Mertens D. Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL.

2019

• Thoene S, Mandal T, Vegi NM, Quintanilla-Martinez L, R枚sler R, Wiese S, Metzeler KH, Herold T, Haferlach T, D枚hner K, D枚hner H, Schwarzm眉ller L, Klingm眉ller U, Buske C, Rawat VPS, Feuring-Buske M. The ParaHox gene Cdx4 induces acute erythroid leukemia in mice.

• Feder K, Edmaier-Schr枚ger K, Rawat VPS, Kirsten N, Metzeler K, Kraus JM, D枚hner K, D枚hner H, Kestler HA, Feuring-Buske M, Buske C. Differences in expression and function of LEF1 isoforms in normal versus leukemic hematopoiesis.

• Wahnschaffe L, Braun T, Timonen S, Giri AK, Schrader A, Wagle P, Almusa H, Johansson P, Bellanger D, L贸pez C, Haferlach C, Stern MH, D眉rig J, Siebert R, Mustjoki S, Aittokallio T, Herling M. JAK/STAT-Activating Genomic Alterations Are a Hallmark of T-PLL. Cancers (Basel).

• Schmidt M, Wiese S, Adak V, Engler J, Agarwal S, Fritz G, Westermark P, Zacharias M, F盲ndrich M. Cryo-EM structure of a transthyretin-derived amyloid fibril from a patient with hereditary ATTR amyloidosis.

• Hoell JI, Ginzel S, Kuhlen M, Kloetgen A, Gombert M, Fischer U, Hein D, Demir S, Stanulla M, Schrappe M, Zur Stadt U, Bader P, Babor F, Schuster F, Strahm B, Alten J, Moericke A, Escherich G, von Stackelberg A, Thiele R, McHardy AC, Peters C, Bornhauser B, Bourquin JP, Krause S, Enczmann J, Meyer LH, Eckert C, Borkhardt A, Meisel R. Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets.

• Gaffo E, Boldrin E, Dal Molin A, Bresolin S, Bonizzato A, Trentin L, Frasson C, Debatin KM, Meyer LH, Te Kronnie G, Bortoluzzi S. Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia.

• Hoock SC, Ritter A, Steinh盲user K, Roth S, Behrends C, Oswald F, Solbach C, Louwen F, Kreis NN, Yuan J. RITA modulates cell migration and invasion by affecting focal adhesion dynamics.
• Bl盲tte TJ, Schmalbrock LK, Skambraks S, Lux S, Cocciardi S, Dolnik A, D枚hner H, D枚hner K, Bullinger L. getITD for FLT3-ITD-based MRD monitoring in AML. Leukemia.

• Liberta F, Rennegarbe M, R枚sler R, Bijzet J, Wiese S, Hazenberg BPC, F盲ndrich M. Morphological and primary structural consistency of fibrils from different AA patients (common variant).

• Jebaraj B, Tausch E, Landau D, Bahlo J, Robrecht S, Taylor-Weiner A, Bloehdorn J, Scheffold A, Mertens D, B枚ttcher S, Kneba M, Jaeger U, Zenz T, Wenger M, Fingerle-Rowson G, Wendtner C, Fink A, Wu C, Eichhorst B, Fischer K, Hallek M, D枚hner H, Stilgenbauer S. Short telomeres are associated with inferior outcome, genomic complexity and clonal evolution in chronic lymphocytic leukemia. Leukemia. 2019 Sep;33(9):2183-2194

• Tausch E, Close W, Dolnik A, Bloehdorn J, Chyla B, Bullinger L, D枚hner H, Mertens D, Stilgenbauer S. Venetoclax resistance and acquired BCL2 mutations in chronic lymphocytic leukemia.

• Edelmann J, Holzmann K, Tausch E, Saunderson EA, Jebaraj BMC, Steinbrecher D, Dolnik A, Bl盲tte TJ, Landau DA, Saub J, Estenfelder S, Ibach S, Cymbalista F, Leblond V, Delmer A, Bahlo J, Robrecht S, Fischer K, Goede V, Bullinger L, Wu CJ, Mertens D, Ficz G, Gribben JG, Hallek M, D枚hner H, Stilgenbauer S. Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1 regulated transcription.

• Lausser L, Sch盲fer LM, Schirra LR, Szekely R, Schmid F, Kestler HA. Assessing phenotype order in molecular data.

• Scheffold A, Jebaraj BMC, Tausch E, Bloehdorn J, Ghia P, Yahiaoui A, Dolnik A, Bl盲tte TJ, Bullinger L, Dheenadayalan RP, Li L, Schneider C, Chen SS, Chiorazzi N, Dietrich S, Seiffert M, Tannheimer S, D枚hner H, Mertens D, Stilgenbauer S. IGF1R as druggable target mediating PI3K-未 inhibitor resistance in a murine model of chronic lymphocytic leukemia.

• Kindermann B, Valkova C, Kr盲mer A, Perner B, Engelmann C, Behrendt L, Kritsch D, Jungnickel B, Kehlenbach RH, Oswald F, Englert C, Kaether C. The nuclear pore proteins Nup88/214 and T-cell acute lymphatic leukemia-associated NUP214 fusion proteins regulate Notch signaling. J

• Bamezai S, Buske C. Cutting Off Leukemogenesis: Hydra-like Plasticity of Mature Leukemic Cells.

• Seyfried F, Demir S, H枚rl RL, Stirnwei脽 FU, Ryan J, Scheffold A, Villalobos- Ortiz M, Boldrin E, Zinngrebe J, Enzenm眉ller S, Jenni S, Tsai YC, Bornhauser B, F眉rstberger A, Kraus JM, Kestler HA, Bourquin JP, Stilgenbauer S, Letai A, Debatin KM, Meyer LH. Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling.

• Hurtado C, Safarova A, Smith M, Chung R, Bruyneel AAN, Gomez-Galeno J, Oswald F, Larson CJ, Cashman JR, Ruiz-Lozano P, Janiak P, Suzuki T, Mercola M. Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ.

• Hecht M, R枚sler R, Wiese S, Johnsson N, Gronemeyer T. An Interaction Network of the Human SEPT9 Established by Quantitative Mass Spectrometry.

• Setz CS, Khadour A, Renna V, Iype J, Gentner E, He X, Datta M, Young M, Nitschke L, Wienands J, Maity PC, Reth M, Jumaa H. Pten controls B-cell responsiveness and germinal center reaction by regulating the expression of IgD BCR.

• Sharman JP, Coutre SE, Furman RR, Cheson BD, Pagel JM, Hillmen P, Barrientos JC, Zelenetz AD, Kipps TJ, Flinn IW, Ghia P, Eradat H, Ervin T, Lamanna N, Coiffier B, Pettitt AR, Ma S, Tausch E, Cramer P, Huang J, Mitra S, Hallek M, O'Brien SM, Stilgenbauer S. Final Results of a Randomized, Phase III Study of Rituximab With or Without Idelalisib Followed by Open-Label Idelalisib in Patients With Relapsed Chronic Lymphocytic Leukemia.

• Hanna BS, Roessner PM, Scheffold A, Jebaraj BMC, Demerdash Y, 脰zt眉rk S, Lichter P, Stilgenbauer S, Seiffert M. PI3K未 inhibition modulates regulatory and  effector T-cell differentiation and function in chronic lymphocytic leukemia.

• Cocciardi S, Dolnik A, Kapp-Schwoerer S, R眉cker FG, Lux S, Bl盲tte TJ, Skambraks S, Kr枚nke J, Heidel FH, Schn枚der TM, Corbacioglu A, Gaidzik VI, Paschka P, Teleanu V, G枚hring G, Thol F, Heuser M, Ganser A, Weber D, Str盲ng E, Kestler HA, D枚hner H, Bullinger L, D枚hner K. Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation.

• Kreis NN, Steinh盲user K, Ritter A, Kl枚ble P, Hoock SC, Roth S, Louwen F, Oswald F, Yuan J. Potential involvement of RITA in the activation of Aurora A at spindle poles during mitosis.

• Van Roosbroeck K, Bayraktar R, Calin S, Bloehdorn J, Dragomir MP, Okubo K, Bertilaccio MTS, Zupo S, You MJ, Gaidano G, Rossi D, Chen SS, Chiorazzi N, Thompson P, Ferrajoli A, Bertoni F, Stilgenbauer S, Keating MJ, Calin GA. miRNAs involvement in the pathogenesis of Richter's syndrome.

• Lyszkiewicz M, Kotlarz D, Zietara N, Brandes G, Diestelhorst J, Glage S, Hobeika E, Reth M, Huber LA, Krueger A, Klein C. LAMTOR2 (p14) controls B cell differentiation by orchestrating endosomal BCR trafficking. Front Immunol. 2019 Mar 18;10:497.

• Liu W, Du W, Shang X, Wang L, Evelyn C, Florian MC, A Ryan M, Rayes A, Zhao X, Setchell K, Meller J, Guo F, Nassar N, Geiger H, Pang Q, Zheng Y. Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization.

• Wilhelm I, Levit-Zerdoun E, Jakob J, Villringer S, Frensch M, 脺belhart R, Landi A, M眉ller P, Imberty A, Thuenauer, R, Claudinon J, Jumaa H, Reth M, Eibel H, Hobeika E, R枚mer W. Carbohydrate-dependent B cell activation by fucose-binding bacterial lectins. Sci Sig,  2019 Mar 5;12(571):eaa0719

• Iype J, Datta M, Khadour A, 脺belhart R, Nicol貌 A, Rollenske T, D眉hren-von Minden M, Wardemann H, Maity PC, Jumaa H. Differences in Self-Recognition between Secreted Antibody and Membrane-Bound B Cell Antigen Receptor.

• Bergmann A, Fataccioli V, Castellano G, Martin-Garcia N, Pelletier L, Ammerpohl O, Bergmann J, Bhat J, Carrillo-de Santa Pau E, Jayne S, Mart铆n-Subero JI, Moffitt AB, Valencia A, Oberg HH, Wesch D, Dyer M, Kabelitz D, Gaulard P, Siebert R, DNA methylation profiling identifies candidate genes involved in the pathogenesis of Hepatosplenic T-cell lymphoma.

• Close V, Close W, Kugler SJ, Reichenzeller M, Yosifov DY, Bloehdorn J, Pan L, Tausch E, Westhoff MA, D枚hner H, Stilgenbauer S, Oswald F, Mertens D (2018) FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL.

• Steinebach C, Kehm K, Lindner S,  Vu, K枚pff S, L贸pez M谩rmol, Weiler C, Wagner K, Reichenzeller M, Kr枚nke J鈥�, G眉tschow M鈥�, PROTAC-mediated crosstalk between E3 ligases.

• Yuan Z, VanderWielen BD, Giaimo BD, Pan L, Collins CE, Turkiewicz A, Hein K, Borggrefe T, Oswald F, Kovall RA (2018) Structural and functional studies of the RBPJ-SHARP complex reveal conserved corepressor binding site.

• Gro脽 A, Kracher B, Kraus JM, K眉hlwein SD, Pfister AS, Wiese S, Luckert K, P枚tz O, Joos T, Van Daele D, De Raedt L, Kestler HA. Representing dynamic biological networks with multi-scale probabilistic models.

• Baur JD, R枚sler R, Wiese S, Johnsson N, Gronemeyer T. Dissecting the nucleotide binding properties of the septins from S. cerevisiae.

2018

• Lausser L, Schmid F, Schirra LR, Wilhelm AFX, Kestler HA. Rank-based classifiers for extremely high-dimensional gene expression data. Adv Data Anal Classif. 2018 12(4): 917-936.

• Maity PC, Datta M, Nicol貌 A, Jumaa H. Isotype Specific Assembly of B Cell Antigen Receptors and Synergism With Chemokine Receptor CXCR4. .

• Hornig NC, Rodens P, D枚rr H, Hubner NC, Kulle AE, Schweikert HU, Welzel M, Bens S, Hiort O, Werner R, Gonzalves S, Eckstein AK, Cools M, Verrijn-Stuart A, Stunnenberg HG, Siebert R, Ammerpohl O, Holterhus PM. Epigenetic Repression of Androgen Receptor Transcription in Mutation-Negative Androgen Insensitivity Syndrome (AIS Type II).

• Tharehalli U, Svinarenko M, Kraus JM, K眉hlwein SD, Szekely R, Kiesle U, Scheffold A, Barth TFE, Kleger A, Schirmbeck R, Kestler HA, Seufferlein T, Oswald F, Katz SF, Lechel A. YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced by Rbpj Deletion.

• Ebert BL, Kr枚nke J. Inhibition of Casein Kinase 1 Alpha in Acute Myeloid Leukemia.

• Wagener R, L贸pez C, Kleinheinz K, Bausinger J, Aukema SM, Nagel I, Toprak UH, Seufert J, Altm眉ller J, Thiele H, Schneider C, Kolarova J, Park J, H眉bschmann D, Murga Penas EM, Drexler HG, Attarbaschi A, Hovland R, Kjeldsen E, Kneba M, Kontny U, de Leval L, N眉rnberg P, Oschlies I, Oscier D, Schlegelberger B, Stilgenbauer S, W枚ssmann W, Schlesner M, Burkhardt B, Klapper W, Jaffe ES, K眉ppers R, Siebert R. IG-MYC-positive neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas.

• Kraus JM, Lausser L, Kuhn P, Jobst F, Bock M, Halanke C, Hummel M, Heuschmann P, Kestler HA. Big data and precision medicine: challenges and strategies with healthcare data. .

• Huehne H, Kessler V, Fuerstberger A, Kuehlwein S, Platzer M, Suehnel J, Lausser L, Kestler HA. 3D Network exploration and visualisation for lifespan data.

• Alsadeq A, Lenk L, Vadakumchery A, Cousins A, Vokuhl C, Khadour A, Vogiatzi F, Seyfried F, Meyer LH, Cario G, Hobeika E, Debatin KM, Halsey C, Schrappe M, Schewe DM, Jumaa H. IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia.

• Brown A, Geiger H. Chromosome integrity checkpoints in stem and progenitor cells: transitions upon differentiation, pathogenesis, and aging.

• Walliser C, Wist M, Hermkes E, Zhou Y, Schade A, Haas J, Deinzer J, D茅sir茅 L, Li SSC, Stilgenbauer S, Milner JD, Gierschik P. Functional characterization of phospholipase C-纬(2) mutant protein causing both somatic ibrutinib resistance and a germline monogenic autoinflammatory disorder.

• Steinebach C, Lindner S, Udeshi ND, Mani DC, Kehm H, K枚pff S, Carr SA, G眉tschow M, Kr枚nke J. Homo-PROTACs for the Chemical Knockdown of Cereblon.

• Florian MC, Klose M, Sacma M, Jablanovic J, Knudson L, Nattamai KJ, Marka G, Vollmer A, Soller K, Sakk V, Cabezas-Wallscheid N, Zheng Y, Mulaw MA, Glauche I, Geiger H. Aging alters the epigenetic asymmetry of HSC division.

• Giaimo BD, Ferrante F, Vallejo DM, Hein K, Gutierrez-Perez I, Nist A, Stiewe T, Mittler G, Herold S, Zimmermann T, Bartkuhn M, Schwarz P, Oswald F, Dominguez M, Borggrefe T. Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response.

• Grigoryan A, Guidi N, Senger K, Liehr T, Soller K, Marka G, Vollmer A, Markaki Y, Leonhardt H, Buske C, Lipka DB, Plass C, Zheng Y, Mulaw MA, Geiger H, Florian MC. LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.

• Leins H, Mulaw M, Eiwen K, Sakk V, Liang Y, Denkinger M, Geiger H, Schirmbeck R. Aged murine hematopoietic stem cells drive aging-associated immune remodeling.

• Hobeika E, Dautzenberg M, Levit-Zerdoun E, Pelanda R, Reth M. Conditional Selection of B Cells in Mice With an Inducible B Cell Development.

• Setz CS, Hug E, Khadour A, Abdelrasoul H, Bilal M, Hobeika E, Jumaa H. PI3K-Mediated Blimp-1 Activation Controls B Cell Selection and Homeostasis.

• Stilgenbauer S, Eichhorst B, Schetelig J, Hillmen P, Seymour JF, Coutre S, Jurczak W, Mulligan SP, Schuh A, Assouline S, Wendtner CM, Roberts AW, Davids MS, Bloehdorn J, Munir T, B枚ttcher S, Zhou L, Salem AH, Desai M, Chyla B, Arzt J, Kim SY, Verdugo M, Gordon G, Hallek M, Wierda WG. Venetoclax for Patients With Chronic Lymphocytic Leukemia With 17p Deletion: Results From the Full Population of a Phase II Pivotal Trial.

• Wang F, Demir S, Gehringer F, Osswald CD, Seyfried F, Enzenm眉ller S, Eckhoff SM, Maier T, Holzmann K, Debatin KM, Wirth T, Meyer LH, Ushmorov A. Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute lymphoblastic leukemia.

• Imkeller K, Scally SW, Bosch A, Mart铆 GP, Costa G, Triller G, Murugan R, Renna V, Jumaa H, Kremsner PG, Sim BKL, Hoffman SL, Mordm眉ller B, Levashina EA, Julien JP, Wardemann H. Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope. Version 2.

• Schmidt K, Zhang Q, Tasdogan A, Petzold A, Dahl A, Arneth BM, Slany R, Fehling HJ, Kranz A, Stewart AF, Anastassiadis K. The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.

• Ushmorov A, Wirth T. FOXO in B-cell lymphopoiesis and B cell neoplasia.

• Schwab JD, Kestler HA. Automatic Screening for Perturbations in Boolean Networks. ang F, Demir S, Gehringer F, Osswald CD, Seyfried F, Enzenm眉ller S, Eckhoff SM, Maier T, Holzmann K, Debatin KM, Wirth T*, Meyer LH*, Ushmorov A. Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute

• lymphoblastic leukemia. *equal contribution

• Trentin L, Queudeville M, Eckhoff SM, Hasan N, M眉nch V, Boldrin E, Seyfried F,Enzenm眉ller S, Debatin KM*, Meyer LH. Leukemia reconstitution in vivo is driven by cells in early cell cycle and low metabolic state. *equal contribution

• Siegle L*, Schwab JD*, K眉hlwein SD*, Lausser L, T眉mpel S, Pfister AS, K眉hl M**, Kestler HA**. A Boolean Network of the Crosstalk Between IGF and Wnt Signaling in Aging Satellite Cells. (* Equal contribution, **Equally contributing joint senior authors).

• Xiao G, Chan LN, Klemm L, Braas D, Chen Z, Geng H, Zhang QC, Aghajanirefah A, Cosgun KN, Sadras T, Lee J, Mirzapoiazova T, Salgia R, Ernst T, Hochhaus A, Jumaa H, Jiang X, Weinstock DM, Graeber TG, M眉schen M. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. .

• Osswald CD, Xie L, Guan H, Herrmann F, Pick SM, Vogel MJ, Gehringer F, Chan FC, Steidl C, Wirth T, Ushmorov A. Fine-tuning of FOXO3A in cHL as a survival mechanism and a hallmark of abortive plasma cell differentiation.

• Bhayadia R, Krowiorz K, Haetscher N, Jammal R, Emmrich S, Obulkasim A, Fiedler J, Schwarzer A, Rouhi A, Heuser M, Wingert S, Bothur S, D枚hner K, M盲tzig T, Ng M, Reinhardt D, D枚hner H, Zwaan CM, van den Heuvel Eibrink M, Heckl D, Fornerod M, Thum T, Humphries RK, Rieger MA, Kuchenbauer F, Klusmann JH. Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia.

• Serrano-Lopez J, Nattamai K, Pease NA, Shephard MS, Wellendorf AM, Sertorio M, Smith EA, Geiger H, Wells SI, Cancelas JA, Privette Vinnedge LM. Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.

• Abdelrasoul H, Werner M, Setz CS, Okkenhaug K, Jumaa H. PI3K induces B-cell development and regulates B cell identity.

• Johansson P, Klein-Hitpass L, Choidas A, Habenberger P, Mahboubi B, Kim B, Bergmann A, Scholtysik R, Brauser M, Lollies A, Siebert R, Zenz T, D眉hrsen U, K眉ppers R, D眉rig J. SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia.
• Mandal T, Beck M, Kirsten N, Lind茅n M, Buske C. Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles. Sci Rep.

• Wolf C, Garding A, Filarsky K, Bahlo J, Robrecht S, Becker N, Zucknick M, Rouhi A, Weigel A, Claus R, Weichenhan D, Eichhorst B, Fischer K, Hallek M, Kuchenbauer F, Plass C, D枚hner H, Stilgenbauer S, Lichter P, Mertens D. NFATC1 activation by DNA hypomethylation in chronic lymphocytic leukemia correlates with clinical staging and can be inhibited by ibrutinib.

• D眉rr C, Hanna BS, Schulz A, Lucas F, Zucknick M, Benner A, Clear A, Ohl S, 脰zt眉rk S, Zenz T, Stilgenbauer S, Li-Weber M, Krammer PH, Gribben JG, Lichter P,  Seiffert M. TNF receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin.

• Wais V, K眉ndgen L, Bohl SR, von Harsdorf S, Schlenk RF, D枚hner K, Teleanu V, Bullinger L, Nguyen TM, Drognitz K, Moulin JC, Binnenhei M, Bentz M, D枚hner H, Bunjes D, Kuchenbauer F, Ringhoffer M. Reduced-toxicity conditioning for allogeneic hematopoietic cell transplantation in elderly or comorbid patients with AML using fludarabine, BCNU and melphalan: disease stage at transplant determines outcome.

• Gaidzik VI, Weber D, Paschka P, Kaumanns A, Krieger S, Corbacioglu A, Kr枚nke J, Kapp-Schwoerer S, Kr盲mer D, Horst HA, Schmidt-Wolf I, Held G, K眉ndgen A, Ringhoffer M, G枚tze K, Kindler T, Fiedler W, Wattad M, Schlenk RF, Bullinger L, Teleanu V, Schlegelberger B, Thol F, Heuser M, Ganser A, D枚hner H, D枚hner K. DNMT3A mutant transcript levels persist in remission and do not predict outcome in patients with acute myeloid leukemia.

• Oswald F, Kovall RA. CSL-Associated Corepressor and Coactivator Complexes.

• Scheffold A, Jebaraj BMC, Stilgenbauer S. Venetoclax: Targeting BCL2 in Hematological Cancers.

• Lausser L*, Schmid F*, Siegle L, H眉hne R, Buchholz M, Kestler HA. Identification of biological mechanisms by semantic classifier systems. bioRxiv 335737, 2018. * Equal contribution

• Brown A. and Geiger H. Role of Cell Cycle Control, Checkpoints and DNA Repair Mechanisms in Stem Cells and Changes with Aging and Cancerogenesis.

2017

• Burkovski A*, Schirra LR*, Schmid F, Lausser L**, Kestler HA**. Ordinal Prototype-Based Classifiers. Archives of Data Science 2(1), 2017. (* Equal contribution, **Equally contributing joint senior authors).

• Greiner J, Hofmann S, Schmitt M, G枚tz M, Wiesneth M, Schrezenmeier H, Bunjes D, D枚hner H, Bullinger L. Acute myeloid leukemia with mutated nucleophosmin 1: an immunogenic acute myeloid leukemia subtype and potential candidate for immune checkpoint inhibition.

• Tiao G, Improgo MR, Tausch E, Fernandes SM, Bahlo J, Robrecht S, Fischer K, Hallek M, Stilgenbauer S, Kiezun A, Getz G, Brown JR. Analysis of ITGB2 rare germ line variants in chronic lymphocytic leukemia.

• Brown A, Pospiech J, Eiwen K, Baker DJ, Moehrle B, Sakk V, Nattamai K, Vogel M, Grigoryan A, Geiger H. The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment.

• Lausser L*, Szekely R*, Schirra LR, Kestler HA. The Influence of Multi-class Feature Selection on the Prediction of Diagnostic Phenotypes. Neural Process Lett, 2017.

• Steinbrecher D, Jebaraj BMC, Schneider C, Edelmann J, Cymbalista F, Leblond V, Delmer A, Ibach S, Tausch E, Scheffold A, Bloehdorn J, Hallek M, Dreger P, D枚hner H, Stilgenbauer S. Telomere length in poor-risk chronic lymphocytic leukemia: associations with disease characteristics and outcome.

• Xiang P, Wei W, Hofs N, Clemans-Gibbon J, Maetzig T, Lai C, Dhillon I, May C, Ruschmann J, Schneider E, Rosten P, Hu K, Kuchenbauer F, Hoodless P, Humphries K.  A knock-in mouse strain facilitates dynamic tracking and enrichment of MEIS1.

• Hirsch S, Bl盲tte TJ, Grasedieck S, Cocciardi S, Rouhi A, Jongen-Lavrencic M, Paschka P, Kronke J, Gaidzik VI, Dohner H, Schlenk RF, Kuchenbauer F, Dohner K, Dolnik A, Bullinger L. Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia.

• Thiel VN, Giaimo BD, Schwarz P, Soller K, Vas V, Bartkuhn M, Bl盲tte TJ, D枚hner K, Bullinger L, Borggrefe T, Geiger H and Oswald F. Heterodimerization of AML1/ETO with CBF尾 is required for leukemogenesis but not for myeloproliferation.

• Scheffold A, Jebaraj BMC, Jaramillo S, Tausch E, Steinbrecher D, Hahn M, B枚ttcher S, Ritgen M, Bunjes D, Zeis M, Stadler M, Uharek L, Scheid C, Hegenbart U, Hallek M, Kneba M, Schmitz N, D枚hner H, Dreger P, Stilgenbauer S. Impact of telomere length on the outcome of allogeneic stem cell transplantation for poor-risk chronic lymphocytic leukaemia: results from the GCLLSG CLL3X trial.

• Herzig JK, Bullinger L, Tasdogan A, Zimmermann P, Schlegel M, Teleanu V, Weber D, R眉cker FG, Paschka P, Dolnik A, Schneider E, Kuchenbauer F, Heidel FH, Buske C, D枚hner H, D枚hner K, Gaidzik VI. Protein phosphatase 4 regulatory subunit 2 (PPP4R2) is recurrently deleted in acute myeloid leukemia and required for efficient DNA double strand break repair.

• Roberts AW, Stilgenbauer S, Seymour JF, Huang DC. Venetoclax in patients with previously treated chronic lymphocytic leukemia.

• Schwarzer A, Emmrich S, Schmidt F, Beck D, Ng M, Reimer C, Adams FF, Grasedieck S, Witte D, K盲bler S, Wong JWH, Shah A, Huang Y, Jammal R, Maroz A, Jongen-Lavrencic M, Schambach A, Kuchenbauer F, Pimanda JE, Reinhardt D, Heckl D, Klusmann JH. The non-coding RNA landscape of human hematopoiesis and leukemia.

• M眉nch V, Trentin L, Herzig J, Demir S, Seyfried F, Kraus JM, Kestler HA, K枚hler R, Barth TFE, Te Kronnie G, Debatin KM, Meyer LH. Central Nervous System Involvement in Acute Lymphoblastic Leukemia Is Mediated by Vascular Endothelial Growth Factor.

• Zajac M, Dolnik A, Stasiak G, Zaleska J, Kielbus M, Czapinski J, Schunn M, Correa SC, Glodkowska-Mrowka E, Sundaram RC, Jankowska O, Schlenk RF, D枚hner H, D枚hner K, Stepulak A, Bullinger L,* Giannopoulos K.* Analysis of NPM1 splice variants reveals differential expression patterns of prognostic value in acute myeloid leukemia.

• Dolezal E, Infantino S, Drepper F, B枚rsig T, Singh A, Wossning T, Fiala GJ, Minguet S, Warscheid B, Tarlinton DM, Jumaa H, Medgyesi D, Reth M. The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex.

• Knittel G, Rehk盲mper T, Korovkina D, Liedgens P, Fritz C, Torgovnick A, Al-Baldawi Y, Al-Maarri M, Cun Y, Fedorchenko O, Riabinska A, Beleggia F, Nguyen PH, Wunderlich FT, Ortmann M, Montesinos-Rongen M, Tausch E, Stilgenbauer S, P Frenzel L, Herling M, Herling C, Bahlo J, Hallek M, Peifer M, Buettner R, Persigehl T, Reinhardt HC. Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia.

• Barth TFE, Kraus JM, Lausser L, Flossbach L, Schulte L, Holzmann K, Kestler HA*, M枚ller P*. Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma.

• Tabaja N, Yuan Z, Oswald F and Kovall RA. Structure-function analysis of RBP-J鈥搃nteracting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes.

• Minici C, Gounari M, 脺belhart R, Scarf貌 L, D眉hren-von Minden M, Schneider D, Tasdogan A, Alkhatib A, Agathangelidis A, Ntoufa S, Chiorazzi N, Jumaa H, Stamatopoulos K, Ghia P, Degano M. Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia.

• Kr枚nke J*,鈥�, Kuchenbauer* F, Kull M, Teleanu V, Bullinger L, Bunjes D, Greiner A, Kolmus S, K枚pff S, Schreder M, M眉gge LO, Straka C, Engelhardt M, D枚hner H, Einsele H, Bassermann F, Bargou R, Knop S*, Langer C*,鈥�. IKZF1 expression is a prognostic marker in newly diagnosed standard-risk multiple myeloma treated with lenalidomide and intensive chemotherapy: a study of the German Myeloma Study Group (DSMM).

• Edenhofer SA, Stilgenbauer S. Chronic Lymphocytic Leukemia with TP53 aberrations: Breakthroughs and Challenges.
  

• Hoenig M, Lagresle-Peyrou C, Pannicke U, Notarangelo LD, Porta F, Gennery AR, Slatter M, Cowan MJ, Stepensky P, Al-Mousa H, Al-Zahrani D, Pai SY, Al Herz W, Gaspar HB, Veys P, Oshima K, Imai K, Yabe H, Noroski LM, Wulffraat NM, Sykora KW, Soler-Palacin P, Muramatsu H, Al Hilali M, Moshous D, Debatin KM, Schuetz C, Jacobsen EM, Schulz AS, Schwarz K, Fischer A, Friedrich W, Cavazzana M; European Society for Blood and Marrow Transplantation (EBMT) Inborn Errors Working Party. Reticular dysgenesis: international survey on clinical presentation, transplantation, and outcome.

• Becker M, Hobeika, E, Jumaa H, Reth M, and Maity PC. CXCR4 signaling and function require the expression of the IgD-class B-cell antigen receptor.
• Gross A, Tasdogan A, Fehling HJ. The IFN-1 > BID > ROS pathway: Linking DNA damage with HSPC malfunction.

• Itkin T, Kumari A, Schneider E, Gur-Cohen S, Ludwig C, Brooks R, Kollet O, Golan K, Khatib-Massalha E, Russo CM, Chisholm JD, Rouhi A, Geiger H, Hornstein E, Kerr WG, Kuchenbauer F*, Lapidot T.* MicroRNA-155 promotes G-CSF-induced mobilization of murine hematopoietic stem and progenitor cells via propagation of CXCL12 signaling. *contributed equally.

• Mohr S, Doebele C, Berg T, Comoglio F, Beck J, Alexe G, Corso J, Bohnenberger H, Str枚bel P, Wachter A, Beissbarth T, Schn眉tgen F, H盲tscher N, G枚llner S, Rouhi A, Palmqvist L, Rieger MA, M眉ller-Tidow C, Kuchenbauer F, Sch眉tz E, Urlaub H, Stegmaier K, Humphries RK, Serve H, Oellerich T. Hoxa9 and Meis1 cooperatively induce addiction to Syk signaling by suppressing miR-146a in acute myeloid leukemia.

• Steinh盲user K, Kl枚ble P, Kreis N, Ritter A, Friemel A, Roth S, Reichel JM, Michaelis J, Rieger MA, Louwen F, Oswald F and Yuan J. Deficiency of RITA results in multiple mitotic defects by affecting microtubule dynamics.

• Bullinger L, D枚hner K, D枚hner H. Genomics of Acute Myeloid Leukemia Diagnosis and Pathways.

• Thielecke L, Aranyossy T, Dahl A, Tiwari R, Roeder I, Geiger H, Fehse B, Glauche I, and Cornils K. Limitations and challenges of genetic barcode quantification.

• Tasdogan A, Kumar S, Allies G, Bausinger J, Beckel F, Hofemeister H, Mulaw M, Madan V, Scharffetter-Kochanek K, Feuring-Buske M, Doehner K, Speit G, Stewart AF, Fehling HJ. DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization.

• Bogen A, Buske C, Hiddemann W, Bohlander SK, Christ O. Variable aldehyde dehydrogenase activity and effects on chemosensitivity of primitive human leukemic cells.

• Edelmann J, Tausch E, Landau DA, Robrecht S, Bahlo J, Fischer K, Fink AM, Bloehdorn J, Holzmann K, B枚ttcher S, Werner L, Kneba M, Gribben JG, Neuberg DS, Wu CJ, Hallek M, D枚hner H, Stilgenbauer S. Frequent evolution of copy number alterations in CLL following first-line treatment with FC(R) is enriched with TP53 alterations: results from the CLL8 trial.

• Gerstung M, Papaemmanuil E, Martincorena I, Bullinger L, Gaidzik VI, Paschka P, Heuser M, Thol F, Bolli N, Ganly P, Ganser A, McDermott U, D枚hner K, Schlenk RF, D枚hner H, Campbell PJ. Precision oncology for acute myeloid leukemia using a knowledge bank approach.

• Fang J, Bolanos LC, Choi K, Liu X, Christie S, Akunuru S, Kumar R, Wang D, Chen X, Greis KD, Stoilov P, Filippi MD, Maciejewski JP, Garcia-Manero G, Weirauch MT, Salomonis N, Geiger H, Zheng Y, and Starczynowski DT. Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.

• Schwab J, Burkovski A, Siegle L, M眉ssel C, Kestler HA. ViSiBooL鈥攙isualization and simulation of Boolean networks with temporal constraints.

• Cusan M, Vegi NM, Mulaw MA, Bamezai S, Kaiser LM, Deshpande AJ, Greif PA, Quintanilla-Fend L, G枚llner S, M眉ller-Tidow C, Humphries KR, Armstrong SA, Hiddemann W, Feuring-Buske M, Buske C. Controlled stem cell amplification by HOXB4 depends on its unique proline-rich region near the N terminus.

• Giaimo BD, Oswald F, Borggrefe T. Dynamic chromatin regulation at Notch target genes.

2016

• Schneider E, Staffas A, R枚hner L, Krowiorz K, Heuser M, D枚hner K, Bullinger L, D枚hner H, Fogelstrand L, Rouhi A, Kuchenbauer F, Palmqvist L. MicroRNA-155 is upregulated in MLL-rearranged AML but its absence does not affect leukemia development.

•  Krowiorz K, Ruschmann J, Lai C, Ngom M, Maetzig T, Martins V, Scheffold A, Schneider E, Pochert N, Miller C, Palmqvist L, Staffas A, Mulaw M, Bohl SR, Buske C, Heuser M, Kraus J, O'Neill K, Hansen CL, Petriv OI, Kestler H, D枚hner H, Bullinger L, D枚hner K, Humphries RK, Rouhi A, Kuchenbauer F. MiR-139-5p is a potent tumor suppressor in adult acute myeloid leukemia.

• Blanc P, Moro-Sibilot L, Barthly L, Jagot F, This S, de Bernard S, Buffat L, Dussurgey S, Colisson R, Hobeika E, Fest T, Taillardet M, Thaunat O, Sicard A, Mondi猫re P, Genestier L, Nutt SL, Defrance T. Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge.

• Gentner E, Vegi NM, Mulaw MA, Mandal T, Bamezai S, Claus R, Tasdogan A, Quintanilla-Martinez L, Grunenberg A, Dohner K, Dohner H, Bullinger L, Haferlach, Buske C, Rawat V and Feuring-Buske M. VENTX induces expansion of primitive erythroid cells and contributes to the development of acute myeloid leukemia in mice.

• Shivarov V, Dolnik A, Lang KM, Kr枚nke J, Kuchenbauer F, Paschka P, Gaidzik VI, D枚hner H, Schlenk RF, D枚hner K, Bullinger L. MicroRNA expression-based outcome prediction in acute myeloid leukemia: novel insights through cross-platform integrative analyses.

• Volkmann C, Brings N, Becker M, Hobeika E, Yang J, and Reth M. Molecular requirements of the B-cell antigen receptor for sensing monovalent antigens.

• Gaidzik VI, Teleanu V, Papaemmanuil E, Weber D, Paschka P, Hahn J, Wallrabenstein T, Kolbinger B, K枚hne CH, Horst HA, Brossart P, Held G, K眉ndgen A, Ringhoffer M, G枚tze K, Rummel M, Gerstung M, Campbell P, Kraus JM, Kestler HA, Thol F, Heuser M, Schlegelberger B, Ganser A, Bullinger L, Schlenk RF, D枚hner K, D枚hner H. RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features.

• Walliser C, Hermkes E, Schade A, Wiese S, Deinzer J, Zapatka M, D茅sir茅 L, Mertens D, Stilgenbauer S, Gierschik P. The phospholipase C纬2 mutants R665W and L845F identified in ibrutinib-resistant chronic lymphocytic leukemia patients are hypersensitive to the Rho GTPase Rac2 protein.

• Taudien S, Lausser L, Giamarellos-Bourboulis EJ, Sponholz C, Sch枚neweck F, Felder M, Schirra L-R, Schmid F, Gogos C, Groth S, Petersen B-S, Franke A, Lieb W, Huse K, Zipfel PF, Kurzai O, Moepps B, Gierschik P, Bauer M, Scherag A, Kestler HA, Platzer M. Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive.

• V枚lkel G, Wiese S, Holzmann K, Kraus JM, Schneider F, G枚rlach M, Kestler HA. TraqBio - Flexible Progress Tracking for Core Unit Projects.

• Schade, A, Walliser, C, Wist, M, Haas, J, Vatter, P, Kraus, J.M, Filingeri, D, Havenith, G, Kestler, H.A, Milner, J.D, Gierschik, P. Cool-temperature-mediated activation of phospholipase C-纬2 in the human hereditary disease PLAID.

• Daria D, Kirsten N, Muranyi A, Mulaw M, Ihme S, Kechter A, Hollnagel M, Bullinger L, D枚hner K, D枚hner H, Feuring-Buske M, Buske C. GPR56 contributes to the development of acute myeloid leukemia in mice.

• Li S,* Garrett-Bakelman FE,* Chung SS, Sanders MA, Hricik T, Rapaport F, Patel J, Dillon R, Vijay P, Brown AL, Perl AE, Cannon J, Bullinger L, Luger S, Becker M, Lewis ID, To LB, Delwel R, L枚wenberg B, D枚hner H, D枚hner K, Guzman ML, Hassane DC, Roboz GJ, Grimwade D, Valk PJ, D'Andrea RJ, Carroll M, Park CY, Neuberg D, Levine R, Melnick AM, Mason CE. Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.

• Vegi NM, Klappacher J, Oswald F, Mulaw MA, Mandoli A, Thiel VN, Bamezai S, Feder K, Martens JHA, Rawat VPS, Mandal T, Quintanilla-Martinez L, Spiekermann K, Hiddemann W, D枚hner K, D枚hner H, Stunnenberg HG, Feuring-Buske M, Buske C. MEIS2 Is an Oncogenic Partner in AML1-ETO-Positive AML.

1st Funding Period (07.2012 - 06.2016)

2016

• Ernst A, Jones DT, Maass KK, Rode A, Deeg KI, Jebaraj BM, Korshunov A, Hovestadt V, Tainsky MA, Pajtler KW, Bender S, Brabetz S, Gr枚bner S, Kool M, Devens F, Edelmann J, Zhang C, Castelo-Branco P, Tabori U, Malkin D, Rippe K, Stilgenbauer S, Pfister SM, Zapatka M, Lichter P. Telomere dysfunction and chromothripsis.

• Oswald F*, Rodriguez P, Giaimo BD, Antonello ZA, Mira L, Mittler G, Thiel VN, Collins KJ, Tabaja N, Cizelsky W, Rothe M, Kuhl SJ, Kuhl M, Ferrante F, Hein K, Kovall RA, Dominguez M and Borggrefe T. A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes.

• Schmid F, Schmid M, M眉ssel C, Str盲ng JE, Buske C, Bullinger L, Kraus JM, Kestler HA. GiANT: gene set uncertainty in enrichment analysis.

• Papaemmanuil E,* Gerstung M,* Bullinger L, Gaidzik VI, Paschka P, Roberts ND, Potter NE, Heuser M, Thol F, Bolli N, Gundem G, Van Loo P, Martincorena I, Ganly P, Mudie L, McLaren S, O'Meara S, Raine K, Jones DR, Teague JW, Butler AP, Greaves MF, Ganser A, D枚hner K, Schlenk RF, D枚hner H,* Campbell PJ* Genomic classification and prognosis in acute myeloid leukemia.

• K枚hrer S, Havranek O, Seyfried F, Hurtz C, Coffey GP, Kim E, Ten Hacken E, J盲ger U, Vanura K, O'Brien S, Thomas DA, Kantarjian H, Ghosh D, Wang Z, Zhang M, Ma W, Jumaa H, Debatin KM, M眉schen M, Meyer LH, Davis RE, Burger JA. Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC, and can be targeted by SYK inhibition.

• Shojaee S, Chan LN, Buchner M, Cazzaniga V, Cosgun KN, Geng H, Qiu YH, von Minden MD, Ernst T, Hochhaus A, Cazzaniga G, Melnick A, Kornblau SM, Graeber TG, Wu H, Jumaa H, M眉schen M. PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.

• Oakes C, Seifert M, Assenov Y, Gu L, Przekopowitz M, Ruppert A, Wang Q, Imbusch CD, Serva A, Koser SD, Brocks D, Lipka D, Bogatyrova O, Weichenhan D, Brors B, Rassenti L, Kipps TJ, Mertens D, Zapatka M, Lichter P, D枚hner H, K眉ppers R, Zenz T, Stilgenbauer S, Byrd JC, Plass C. DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia.

• Staffas A, Arabanian L, Yuan Wei S, Jansson A, St氓hlman S, Johansson P, Fogelstrand L, Cammenga J, Kuchenbauer F, Palmqvist L. Up-regulation of Flt3 is a passive event in Hoxa9/Meis1 induced acute myeloid leukemia in mice.

• Tasdogan A, Kumar S, Allies G, Bausinger J, Beckel F, Hofemeister H, Mulaw M, Madan V, Scharffetter-Kochanek K, Feuring-Buske M, Doehner K, Speit G, Stewart AF, Fehling HJ. DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization.

• Borggrefe T, Lauth M, Zwijsen A, Huylebroek D, Oswald F, Giaimo BD. The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGF尾/BMP and hypoxia pathways.

• Riehl LM, Schulte JH, Mulaw MA, Dahlhaus M, Fischer M, Schramm A, Eggert A, Debatin KM, Beltinger C. The mitochondrial genetic landscape in neuroblastoma from tumor initiation to relapse.

• Dahlhaus M, Burkovski A, Hertwig F, M眉ssel C, Volland R, Fischer M, Debatin KM, Kestler HA, Beltinger C. Boolean modeling identifies Greatwall/MASTL as an important regulator in the AURKA network of neuroblastoma.

• M眉ssel C, Schmid F, Bl盲tte TJ, Hopfensitz M, Lausser L, Kestler HA. BiTrinA 鈥� multiscale binarization and trinarization with quality analysis.

• Fischer K, Bahlo J, Fink AM, Goede V, Herling CD, Cramer P, Langerbeins P, von Tresckow J, Engelke A, Maurer C, Kovacs G, Herling M, Tausch E, Kreuzer KA, Eichhorst B, B枚ttcher S, Seymour JF, Ghia P, Marlton P, Kneba M, Wendtner CM, D枚hner H, Stilgenbauer S, Hallek M. Long-term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: updated results of the CLL8 trial. .

• Schirmer M, Trentin L, Queudeville M, Seyfried F, Demir S, Tausch E, Stilgenbauer S, Eckhoff SM, Meyer LH, Debatin KM. Intrinsic and chemo-sensitizning activity of SMAC-mimetics on high-risk acute lymphoblastic leukemia.

• Lausser L, Schmid F, Kestler HA. Semantic multi-classifier systems for the analysis of gene expression profiles. Archives of Data Science. 2016;1(1).

2015

• Moehrle BM, Nattamai K, Brown A, Florian MC, Ryan M, Vogel M, Bliederhaeuser C, Soller K, Prows DR, Abdollahi A, Schleimer D, Walter D, Milsom MD, Stambrook P, Porteus M, Geiger H. Stem cell specific mechanisms ensure genomic fidelity within HSCs and upon aging of HSCs.

• Reichwald K, Petzold A, Koch P, Downie BR, Hartmann N, Pietsch S, Baumgart M, Chalopin D, Felder M, Bens M, Sahm A, Szafranski K, Taudien S, Groth M, Arisi I, Weise A, Bhatt SS, Sharma V, Kraus JM, Schmid F, Priebe S, Liehr T, Goerlach M, Than M, Hiller M, Kestler HA, Volff JN, Schartl M, Cellerino A, Englert C, Platzer M. Insights into sex chromosome evolution and aging from the genome of a short-lived fish.

• Schneider V, Zhang L, Rojewski M, Fekete N, Schrezenmeier H, Erle A, Bullinger L, Hofmann S, Gotz M, D枚hner K, Ihme S, D枚hner H, Buske C, Feuring-Buske M, Greiner J. Leukemic progenitor cells are susceptible to targeting by stimulated cytotoxic T cells against immunogenic leukemia-associated antigens.

• Gentner B, Pochert N, Rouhi A, Boccalatte F, Plati T, Berg T, Sun SM, Mah S, Mirkovic-H枚sle M, Ruschmann J, Muranyi A, Leierseder S, Argiropoulos B, Starczynowski DT, Karsan A, Heuser M, Hogge D, Camargo FD, Engelhardt S, D枚hner H, Buske C, Jongen-Lavrencic M, Naldini L, Humphries RK, Kuchenbauer F. MicroRNA-223 dose-levels fine-tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia.

• Landau DA, Tausch E, Taylor-Weiner AN, Stewart C, Reiter JG, Bahlo J, Kluth S, Bozic I, Lawrence M, B枚ttcher S, Carter SL, Cibulskis K, Mertens D, Sougnez CL, Rosenberg M, Hess JM, Edelmann J, Kless S, Kneba M, Ritgen M, Fink A, Fischer K, Gabriel S, Lander ES, Nowak MA, D枚hner H, Hallek M,* Neuberg D,* Getz G*, Stilgenbauer S*, Wu CJ*.Mutations driving CLL and their evolution in progression and relapse.

• Walliser C, Tron K, Clauss K, Gutman O, Kobitski AY, Retlich M, Schade A, R枚cker C, Henis YI, Nienhaus GU, Gierschik P. Rac-mediated stimulation of phospholipase C蠏2 amplifies B cell receptor-induced calcium signaling.

• Zirafi O, Kim KA, Standker L, Mohr KB, Sauter D, Heigele A, Kluge SF, Wiercinska E, Chudziak D, Richter R, Moepps B, Gierschik P, Vas V, Geiger H, Lamla M, Weil T, Burster T, Zgraja A, Daubeuf F, Frossard N, Hachet-Haas M, Heunisch F, Reichetzeder C, Galzi JL, Perez-Castells J, Canales-Mayordomo A, Jimenez-Barbero J, Gimenez-Gallego G, Schneider M, Shorter J, Telenti A, Hocher B, Forssmann WG, Bonig H, Kirchhoff F, Munch J. Discovery and characterization of an endogenous CXCR4 antagonist.

• Frishman-Levy L, Shemesh A, Bar-Sinai A, Ma C, Ni Z, Frenkel S, Muench V, Bruckmueller H, Vokuhl C, Debatin KM, Eckert C, Stanulla M, Schrappe M, Campbell KS, Loewenthal R, Schewe DM, Hochman J, Meyer LH, Kaufman D, Cario G, Porgador A, Izraeli S. Central nervous system acute lymphoblastic leukemia: role of natural killer cells.

• V枚lkel G, Lausser L, Schmid F, Kraus JM, Kestler HA. Sputnik: ad hoc distributed computation.

• F眉rstberger A, Maucher M, Kestler HA. Extended pairwise local alignment of wild card DNA/RNA sequences using dynamic programming. Journal of Statistical Computation and Simulation. 2015; 85(1):3-13.

• Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, Dik TP, Holland-Letz T, Schmezer P, Lane SW, Rieger MA, Essers MA, Williams DA, Trumpp A, Milsom MD. Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.

• Hein K, Mittler G, Cizelsky W, Kuhl M, Ferrante F, Liefke R, Berger IM, Just S, Strang JE, Kestler HA, Oswald F, Borggrefe T. Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response.

• Hasan MN, Queudeville M, Trentin L, Eckhoff SM, Bronzini I, Palmi C, Barth T, Cazzaniga G, Te Kronnie G, Debatin KM, Meyer LH. Targeting of hyperactivated mTOR signaling in high-risk acute lymphoblastic leukemia in a pre-clinical model.

 2014

• Schlenk RF, Kayser S, Bullinger L, Kobbe G, Casper J, Ringhoffer M, Held G, Brossart P, L眉bbert M, Salih HR, Kindler T, Horst HA, Wulf G, Nachbaur D, G枚tze K, Lamparter A, Paschka P, Gaidzik VI, Teleanu V, Sp盲th D, Benner A, Krauter J, Ganser A, D枚hner H, D枚hner K. Differential impact of allelic ratio and insertion site in FLT3-ITD positive AML with respect to allogeneic transplantation.

• Stadler CR, Vegi N, Mulaw MA, Edmaier KE, Rawat VP, Dolnik A, Bullinger L, Heilmeier B, Quintanilla-Fend L, Spiekermann K, Hiddemann W, D枚hner K, D枚hner H, Feuring-Buske M and Buske C. The leukemogenicity of Hoxa9 depends on alternative splicing.

• Qu Y, Lennartsson A, Gaidzik VI, Deneberg S, Karimi M, Bengtz茅n S, H枚glund M, Bullinger L, D枚hner K, Lehmann S. Differential methylation of CN-AML is preferentially targeting non-CGI regions and is dominated by DNMT3A mutational status associated with global hypomethylation, preferentially targeting the homeobox gene family.

• Tausch E, Mertens D, Stilgenbauer S. Advances in treating chronic lymphocytic leukemia.

• Woyach J, Furman R, Liu T, Ozer H, Zapatka M, Ruppert A, Xue L, Li D, Steggerda S, Versele M, Dave S, Zhang J, Yilmaz A, Jaglowski S, Blum K, Lozanski A, Lozanski G, James D, Barrientos J, Lichter P, Stilgenbauer S, Buggy J, Chang B, Johnson A, Byrd J. Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib.

• L眉hl NC, Zirngibl F, Dorneburg C, Wei J, Dahlhaus M, Barth TF, Meyer LH, Queudeville M, Eckhoff S, Debatin KM, Beltinger C. Attenuated measles virus controls pediatric acute B-lineage lymphoblastic leukemia in NOD/SCID mice.

• Pastore F, Dufour A, Benthaus T, Metzeler KH, Maharry KS, Schneider S, Ksienzyk B, Mellert G, Zellmeier E, Kakadia PM, Unterhalt M, Feuring-Buske M, Buske C, Braess J, Sauerland MC, Heinecke A, Krug U, Berdel WE, Buechner T, Woermann B, Hiddemann W, Bohlander SK, Marcucci G, Spiekermann K, Bloomfield CD and Hoster E. Combined molecular and clinical prognostic index for relapse and survival in cytogenetically normal acute myeloid leukemia.

• Stilgenbauer S, Schnaiter A, Paschka P, Zenz T, Rossi M, D枚hner K, Buhler A, Bottcher S, Ritgen M, Kneba M, Winkler D, Tausch E, Hoth P, Edelmann J, Mertens D, Bullinger L, Bergmann M, Kless S, Mack S, Jager U, Patten N, Wu L, Wenger M, Fingerle-Rowson G, Lichter P, Cazzola M, Wendtner C, Fink A, Fischer K, Busch R, Hallek M, D枚hner H. Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial.

• Mertens D, Stilgenbauer S. Prognostic and predictive factors in patients with chronic lymphocytic leukemia: relevant in the era of novel treatment approaches?

• Kredel S, Wolff M, Gierschik P, Heilker R. Phenotypic analysis of chemokine-driven actin reorganization in primary human neutrophils.

• Edmaier KE, Stahnke K, Vegi N Mulaw M, Ihme S, Scheffold A, Rudolph KL, Buske C. Expression of the lymphoid enhancer factor 1 is required for normal hematopoietic stem and progenitor cell function.

• Lausser L, Schmid F, Schmid M, Kestler HA. Unlabeling data can improve classification accuracy. Pattern Recognition Letters. 2014;37:15-23.

2013

• Florian MC, Nattamai KJ, D枚rr K, Marka G, Uberle B, Vas V, Eckl C, Andr盲 I, Schiemann M, Oostendorp RA, Scharffetter-Kochanek K, Kestler HA, Zheng Y, Geiger H. A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.

• Zhou X, Florian MC, Arumugam P, Chen X, Cancelas JA, Lang R, Malik P, Geiger H, Zheng Y. RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors.

• Grasedieck S, Sorrentino A, Langer C, Buske C, D枚hner H, Mertens D, Kuchenbauer F. Circulating microRNAs as biomarkers in hematological diseases: principles, challenges and perspectives.

• Wu Y, Ihme S, Feuring-Buske M, Kuan SL, Eisele K, Lamla M, Wang Y, Buske C and Weil T. A core-shell albumin copolymer nanotransporter for high capacity loading and two-step release of doxorubicin with enhanced anti-leukemia activity.

• Geiger H, de Haan G, Florian MC. The ageing haematopoietic stem cell compartment.

• Jung C, Mittler G, Oswald F, Borggrefe T. RNA helicase Ddx5 and the noncoding RNA SRA act as coactivators in the Notch signaling pathway. Biochim Biophys Acta.

• Jebaraj BM, Kienle D, Lechel A, Mertens D, Heuberger M, Ott G, Rosenwald A, Barth TF, M枚ller P, Zenz T, D枚hner H, Stilgenbauer S. Telomere length in mantle cell lymphoma.

• Dreger P, Schnaiter A, Zenz T, Bottcher S, Rossi M, Paschka P, Buhler A, Dietrich S, Busch R, Ritgen M, Bunjes D, Zeis M, Stadler M, Uharek L, Scheid C, Hegenbart H, Hallek M, Kneba , Schmitz, D枚hner, Stilgenbauer S. TP53, SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia: six-year follow-up of the GCLLSG CLL3X trial.

• Schnaiter A, Paschka P, Rossi M, Zenz T, Buhler A, Winkler D, Cazzola M, D枚hner K, Edelmann J, Mertens D, Kless S,  Mack S, Busch R, Hallek M, D枚hner H, Stilgenbauer S. NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG.

• Kr枚nke J, Bullinger L, Teleanu V, Tsch眉rtz F, Gaidzik VI, K眉hn MWM, R眉cker FG, Holzmann K, Paschka P, Kapp-Schw枚rer S, Sp盲th D, Kindler T, Schittenhelm M, Krauter J, Ganser A, G枚hring G, Schlegelberger B, Schlenk RF, D枚hner H, D枚hner K. Clonal evolution in relapsed NPM1 mutated acute myeloid leukemia.

• Bullinger L, Schlenk RF, G枚tz M, Botzenhardt U, Hofmann S, Russ AC, Babiak A, Zhang L, Schneider V, D枚hner K, Schmitt M, D枚hner H, Greiner J. PRAME induced inhibition of retinoic acid receptor signaling-mediated differentiation 鈥� a possible target for ATRA response in AML without t(15;17). Clin

• Gaidzik VI, Schlenk RF, Paschka P, Stoelzle A, Spaeth D, Kuendgen A, von Lilienfeld-Toal M, Brugger W, Derigs HG, Kremers S, Greil R, Raghavachar A, Ringhoffer M, Salih HR, Wattad M, Kirchen HG, Runde V, Heil G, Petzer AL, Girschikofsky M, Heuser M, Kayser S, G枚hring G, Teleanu MV, Schlegelberger B, Ganser A, Krauter J, Bullinger L, D枚hner H, D枚hner K. Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG).

2012

• Gierschik P, Buehler A, Walliser C. Activated PLC蠏 breaking loose.

• Grasedieck S, Sch枚ler N, Bommer M, Niess JH, Tumani H, Rouhi A, Bloehdorn J, Liebisch P, Mertens D, D枚hner H, Buske C, Langer C, Kuchenbauer F. Impact of serum storage conditions on microRNA stability. Leukemia.

• Metzeler KH, Heilmeier B, Edmaier KE, Rawat VP, Dufour A, D枚hner K, Feuring-Buske M, Braess J, Spiekermann K, Buchner T, Sauerland MC, D枚hner H, Hiddemann W, Bohlander SK, Schlenk RF, Bullinger L, Buske C.  High expression of lymphoid enhancer-binding factor-1 (LEF1) is a novel favorable prognostic factor in cytogenetically normal acute myeloid leukemia.

• Vas V, Senger K, Dorr K, Niebel A, Geiger H. Aging of the microenvironment influences clonality in hematopoiesis.

• Geiger H, Pawar SA, Kerschen EJ, Nattamai KJ, Hernandez I, Liang HP, Fernandez JA, Cancelas JA, Ryan MA, Kustikova O, Schambach A, Fu Q, Wang J, Fink LM, Petersen KU, Zhou D, Griffin JH, Baum C, Weiler H, Hauer-Jensen M. Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity.

• Rawat VP, Humphries RK, Buske C. Beyond Hox: the role of ParaHox genes in normal and malignant hematopoiesis.

• Metzeler KH, Heilmeier B, Edmaier KE, Hoster E, Metzeler KH, Herold T, Hiddemann W, Gokbuget N, Hoelzer D, Bohlander SK, Feuring-Buske M, Buske C. High expression of lymphoid enhancer-binding factor-1 (LEF1) is a novel favorable prognostic factor in cytogenetically normal acute myeloid leukemia.

• Schneider F, Hoster E, Unterhalt M, Schneider S, Dufour A, Benthaus T, Mellert G, Zellmeier E, Kakadia PM,  Bohlander SK, Feuring-Buske M, Buske C, Braess J, Heinecke A, Sauerland MC, Berdel WE, Buchner T, Wormann BJ, Hiddemann W and Spiekermann K. The FLT3ITD mRNA level has a high prognostic impact in NPM1 mutated, but not in NPM1 unmutated, AML with a normal karyotype.

• Schneider F, Hoster E, Schneider S, Dufour A, Benthaus T, Kakadia PM, Bohlander SK, Braess J, Heinecke A, Sauerland MC, Berdel WE, Buechner T, Woermann BJ, Feuring-Buske M, Buske C, Creutzig U, Thiede C,  Zwaan MC, van den Heuvel-Eibrink MM, Reinhardt D, Hiddemann W, Spiekermann K. Age-dependent frequencies of NPM1 mutations and FLT3-ITD in patients with normal karyotype AML (NK-AML).

• Schmohl M, Rimmele S, Gierschik P, Joos TO, Schneiderhan-Marra N. Functional analysis of Rho GTPase activation and inhibition in a bead-based miniaturized format.

• Edelmann J, Holzmann K, Miller F, Winkler D, Buhler A, Zenz T, Bullinger T, Kuhn MW, Gerhardinger A, Bloehdorn J, Radtke I, Su X, Ma J, Pounds S, Hallek M, Lichter P, Korbel J, Busch R, Mertens D, Downing, Stilgenbauer, D枚hner H. High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations.

• Queudeville M, Seyfried F, Eckhoff SM, Trentin L, Ulrich S, Schirmer M, Debatin KM, Meyer LH. Rapid engraftment of human ALL in NOD/SCID mice involves deficient apoptosis signaling.